The aim of the talk is to introduce some notions about cortical modeling with a focus on cortical columns. In the first part, I introduce cortical columns from a biological point of view and point out why the notion of cortical column is complex. In the second part, I describe Jansen’s model of a single cortical column and discuss its adequacy to biological facts. The third and last part shows ...

Abstract Malformations of cortical development are rarely diagnosed in utero. Cortical malformations aberrations the process corticogenesis. We report two rare and unique cases evolving malformation with unusual ultrasonogram markers: (1) narrow cavum septum pellucidum (2) ill-defined irregular lateral ventricular borders on midtrimester anomaly scan. This was further confirmed by fetal brain e...

To obtain drugs which are more selective at benzodiazepine (BZD) receptors, design and synthesis of functionally selective ligands for BZD receptors is the current strategy of our pharmaceutical chemistry department. The affinity of newly synthesized ligands is assessed by radioligand receptor binding assays. Based on our previous studies, 2-phenyl-5-oxo-7-methyl-1,3,4-oxadiazolo[a,2,3]-pyrimid...

Abstract Introduction Recurrent arousals in obstructive sleep apnea (OSA) may lead to alteration functional connection involving the ascending reticular activating system (ARAS). We aimed evaluate resting-state connectivity (FC) between eight ARAS nuclei and 105 cortical/subcortical regions OSA patients matched controls. Methods Total of 50 with moderate severe 20 controls without underwent ove...

hydronephrosis occurs as a congenital or an acquired condition following obstruction of the urinary tract. in this study, a four month old male holstein calf with emaciation, growth retardation and a poor dry scruffy hair coat was examined because of remarkable distention of right abdomen. at necropsy, right kidney was hydronephrotic as a very big fluid-filled round pelvis with the presence of ...

In 15 patients with essential hypertension total blood flow to a single kidney (TRBF) was measured by a constant infusion indicator-dilution technic which had previously been validated in dogs. Indocyanine green indicator-dilution curves then were used to calculate the fraction of renal flow traversing the rapid (cortical) circulation and the blood volume in this cortical compartment. TRBF rang...

Cortical spreading depression is a pathophysiological event shared in migraines, strokes, traumatic brain injuries, and epilepsy. It associated with complex hemodynamic responses, which, turn, contribute to neurological problems. In this study, we investigated the role of canonical transient receptor potential channel 3 (TRPC3) responses elicited by cortical depression. Cerebral blood flow was ...