Despite numerous studies reported during the past six years, the controversy concerning the effects of ACTH and cortisone on tuberculous infections continues. When one considers the many known and unknown factors that influence host-parasite relationships, the different reactions of different species to tuberculous infections, and the varied effects of different drugs and hormones on the infect...

Ttiis is a useful book, in which the place of cortisone and other steroid drugs in the treatment of the rheumatic diseases is reviewed. The book falls naturally into two parts. The first section conisists of five chapters, and is concerned with the use of cortisone in rheumatoid arthritis. The second section consists of two chapters, the first of which decribes the general use of cortisone in d...

NUMEROUS recent reports show that cortisone apparently exerts an inhibitory effect, both clinically and in experimental animals, on mesenchymal growth; the evidence on its effect upon epithelial cells is less conclusive. This work has been reviewed by Duke-Elder and Ashton (1951). The object of the experiments here reported is to elucidate the action of cortisone on growth in tissue cultures an...

In recent years there has been an increasing tendency to determine the intracellular action of hormones. Many hormones are known to have an effect on carbohydrate metabolism in general and on carbohydrate oxidation and adenosine triphosphate synthesis in particular. Previous work in this laboratory has shown that the efficiency of oxidative phosphorylation is depressed in insulin-deficient anim...

1. The activities of gluconeogenic and glycolytic enzymes and the concentrations of citrate, ammonia, amino acids, glycogen, glucose 6-phosphate, acetyl-CoA, lactate and pyruvate were measured in kidney cortex of normal, diabetic, cortisone-treated and growth hormone-treated rats. 2. In kidney cortex of diabetic, cortisone-treated and growth hormone-treated rats the activities of glucose 6-phos...

Recent efforts have provided convincing evidence for the use of fish scale cortisol concentration in assessment long-term stress fishes. However, alone is not sufficient to fully describe this state stress. Dehydroepiandrosterone (DHEA) an androgen with actions that oppose those cortisol. The means by which DHEA negates effects occurs part via changes metabolism cortisone. quantitation cortisol...

BACKGROUND It has been unclear whether relatively high cortisol and cortisone levels are related to overweight in childhood, parental body mass index (BMI), and family dietary habits. The aim of this study was to compare cortisol and cortisone levels in urine and saliva from overweight and normal children, as well as correlations between children's BMI, parental BMI and family dietary behavior ...

11β-Hydroxysteroid dehydrogenase type 1 (11βHSD1) is a therapeutic target in metabolic syndrome because it catalyses reductase regeneration of cortisol from cortisone in adipose and liver. 11βHSD1 can also catalyze the reverse dehydrogenase reaction in vitro (e.g., if cofactor is limited). We used stable isotope tracers to test the hypothesis that both 11βHSD1-reductase and -dehydrogenase activ...