Effective parameters that can effect on the performance of the separation system consist of operating pressure, operating temperature, reflux ratio, and kind of produce desirable products and different sequences of splits. As take a separation system with optimal performance is dependent on optimization of above mentioned effective parameters. In generally, there are two criteria (as object fun...

BACKGROUND & AIMS Availability of directly-acting antivirals (DAAs) has changed the treatment landscape of hepatitis C virus (HCV) infection. The high price of DAAs has restricted their use in several countries. However, in some countries such as India, generic DAAs are available at much cheaper price. This study examined whether generic DAAs could be cost-saving and how long it would take for ...

BACKGROUND Decisions on the timing and extent of vaccination against pandemic (H1N1) 2009 virus are complex. OBJECTIVE To estimate the effectiveness and cost-effectiveness of pandemic influenza (H1N1) vaccination under different scenarios in October or November 2009. DESIGN Compartmental epidemic model in conjunction with a Markov model of disease progression. DATA SOURCES Literature and ...

OBJECTIVE To determine a cost-minimizing option for congenital toxoplasmosis in the United States. METHODOLOGY/PRINCIPAL FINDINGS A decision-analytic and cost-minimization model was constructed to compare monthly maternal serological screening, prenatal treatment, and post-natal follow-up and treatment according to the current French (Paris) protocol, versus no systematic screening or perinat...