Mitochondrial pyruvate carrier 1 (MPC1) and MPC 2 form a transporter complex in cells to control pyruvate transportation into mitochondria. Reduced expression of MPC1 disrupts the transporter function, induces metabolic shift to increase glycolysis, and thus plays important roles in several diseases, including cancer. However, the role of MPC1 in prostate cancer and the underlying mechanism cau...

Myanmar is in a dangerous and uncertain moment following the military coup on 1 February 2021. The articles this Special Forum provide timely contextual analysis. Written before coup, ar...

Military coup d’etats are the worst enemies of national unity. Coup divides and debases a free people. If there was any doubt on subject, events in Pakistan have shown that peop...

Although the 2011 uprisings in Egypt led to the fall of Hosni Mubarak, they have not yet been able to change the nature of the country’s political system. A year after the country’s first non-military president took office, Egypt’s political situation became more or less similar to the way it had been before 2011. The structure of the relationship between the state and the society in Egypt, hig...

Chicken ovalbumin upstream promotor-transcription factor I (COUP-TFI), an orphan member of the nuclear receptor superfamily, is highly expressed in the developing nervous systems. In the cerebral cortex of Coup-tfl mutants, cortical layer IV was absent due to excessive cell death, a consequence of the failure of thalamocortical projections. Moreover, subplate neurons underwent improper differen...

The COUP (chicken ovalbumin upstream promoter) transcription factor binds to the upstream promoters of both the chicken ovalbumin and the rat insulin II genes, even though the two binding sites have no obvious sequence similarity (Hwung, Y.-P., Crowe, D. T., Wang, L.-H., Tsai, S. Y., and Tsai, M.-J. (1988) Mol. Cell. Biol. 8, 2070-2077). Comparison of the contact points and important nucleotide...

While the cortical interneurons derived from the medial ganglionic eminence (MGE) migrate rather diffusely into the cortex, interneurons that migrate out from the caudal ganglionic eminence (CGE) mainly move caudally into the caudal cerebral cortex and the hippocampus in the form of the caudal migratory stream (CMS) (Yozu et al., 2005). Although transplantation experiments at embryonic day 13.5...

The mesenchymal cell is a multipotent stem cell with the capacity to give rise to multiple cell types such as adipocytes, osteoblasts, chondrocytes, and myocytes. However, the molecular events responsible for their lineage specification and differentiation remain obscure. Here we show that inactivation of chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII), a member of the n...

Genes that control the specification and differentiation of the functionally specialized areas of the mammalian neocortex are likely expressed across the developing neocortex in graded or restricted patterns. To search for such genes we have performed a PCR-based differential display screen using RNAs from rostral neocortex, which included the primary motor area, and caudal neocortex, which inc...