We studied the effect of prostate resection on serum creatine kinase (EC 2.7.3.2) and lactate dehydrogenase (EC 1.1.1.27) isoenzymes in 22 patients. Two hours after their operations, two-thirds of these patients had increased total creatine kinase activity. The MB isoenzyme was demonstrated in sera of 66% of the patients and the BB isoenzyme in 76%. MB content varied from 1 to 7% of total creat...

A 65-year-old woman failed to develop increased creatine kinase or lactate dehydrogenase activity after a myocardial infarction. She had no measurable creatine kinase MB isoenzyme and no detectable patterns of normal LD isoenzyme activity. These determinations five months after the infarction showed normal values for total activity and isoenzyme patterns.

To determine the intracellular source and release kinetics of myosin light chain 1 immediately following irreversible myocytic injury, we perfused rat hearts in a Langendorff apparatus under control conditions (20 minutes), or during global cellular injury produced by oxygenated, calcium-free perfusion (5 minutes), followed by reperfusion with buffer containing 2.5 mM calcium (15 minutes). Ligh...

1 Experimental Physiopathology Laboratory, Postgraduation Program in Health Sciences, Universidade do Extremo Sul Catarinense, Criciúma (SC), Brazil 2 Neuroscience Laboratory, Postgraduation Program in Health Sciences, Universidade do Extremo Sul Catarinense, Criciúma (SC), Brazil Abstract Objective: Clinical findings suggest that ketamine may be used for the treatment of major depression. The ...

Creatine Kinase and the Correlates of Blood Pressure in a Random Population Sample To the Editor: We hypothesized that creatine kinase (CK), the central regulatory enzyme of energy metabolism, amplifies blood pressure responses, and subsequently showed that CK activity is independently associated with blood pressure.1 CK catalyzes the reversible transfer of the high-energy phosphate moiety (P) ...

Based on electrocardiographic criteria, coronary artery bypass grafting patients were divided into two groups, one with and one without perioperative myocardial infarction. Serial total-creatine kinase activity did not discriminate between the two groups; however, serial creatine kinase-MB activity showed a consistent difference. Patients with perioperative myocardial infarction showed an incre...