Pellagra is a nutritional disease caused by the deficiency of niacin. We describe a case of pellagra as the initial presentation of Crohn disease, which has been rarely described in the literature.

Careful examination of the oral cavity may reveal findings indicative of an underlying systemic condition, and allow for early diagnosis and treatment. Examination should include evaluation for mucosal changes, periodontal inflammation and bleeding, and general condition of the teeth. Oral findings of anemia may include mucosal pallor, atrophic glossitis, and candidiasis. Oral ulceration may be...

Extraintestinal respiratory manifestations in inflammatory bowel disease (IBD) are rare. We present a case of bronchiolitis obliterans organizing pneumonia (BOOP) in a patient with Crohn s disease, with clinical remission with no drug therapy.

症例は36歳，女性．18歳時にCrohn病を発症し，痔瘻を含む大腸病変の増悪のため28歳時に回腸人工肛門造設を施行されている．8年後，大腸病変および直腸周囲膿瘍の再燃のため大腸全摘術を施行したところ，回腸断端～結腸・直腸全域にわたって無数に重複する同時多発性のCrohn病関連癌が診断された．Crohn病の長期経過に伴い炎症性病変を母地とした癌が発生することは周知されているが，潰瘍性大腸炎の場合のように多発癌に関しては本邦ではまだ議論がなされていない．本邦におけるCrohn病関連癌の疫学が著しく欧米と異なるため，癌に対するサーベイランス方の確立途上であることも一因と思われる．疫学や治療法に対する欧米と本邦の差異を考察に加え報告する．

Crohn disease is a complex pathologic process with an unpredictable lifelong course that includes frequent relapses. It often affects young patients, who are most vulnerable to the potential adverse effects of repeated exposure to ionizing radiation from computed tomography performed for diagnosis and surgical planning. The small intestine is the bowel segment that is most frequently affected, ...

The frequency of Crohn disease shows a significant increase in the last century. Affected patients show a misbalance between production of free radicals and anti oxidant defenses. Thus, one of the increasingly accepted htypotheses to explain the origin of this disease, is the oxidative stress that occurs in the intestinal mucosa. Dietary factors including self administered vitamin and mineral s...

A 25-year-old woman with a history of multiple medical problems including a distal pancreatectomy and splenectomy 6 months earlier for pancreatic mass (solid pseudopapillary tumor with negative margins), systemic lupus erythematous (SLE), Crohn disease, and a history of alcohol abuse presented to her pain management physician with weakness, decreased appetite, worsening joint pain, abdominal pa...