Evolutionary approaches to molecular docking typically use a realvalue encoding with standard genetic operators. Mutation is usually based on Gaussian and Cauchy distributions whereas for crossover no special considerations are made. The choice of operators is important for an efficient algorithm for this problem. We investigate their effect by performing a locality, heritability and heuristic ...

OBJECTIVES The validity of a new sham acupuncture technique was tested on acupuncture naïve healthy subjects. METHODS The procedure was tested in accupoints LI4 and ST6 in a randomised, single blind and crossover study. The participants were blind to which technique they received. 32 healthy volunteers (15 men, 17 women, aged between 20 and 62 years, mean age 34 years) were recruited at the U...

OBJECTIVES Percutaneous transluminal angioplasty with stenting is perceived to be a less invasive and cheaper option for the treatment of iliac artery occlusion than surgical reconstruction. We have carried out a prospective observational study of all patients undergoing an iliac stent or femorofemoral crossover graft for iliac artery occlusion to assess the cost effectiveness of the two approa...

We study some theoretical aspects of strongly coupled quark gluon plasma, as a function of Coulomb coupling parameter Γ. We study the evaluation of dynamic properties of the BCS/BEC crossover in relativistic fluid. We also discuss some fluid dynamic aspects of the crossover at critical temperature. The shear viscosity is minimum near around the unitary limit. We have clarified the thermal fluct...

We study the dynamics of an intriguing crossover from a chaotic to a power-law state as a function of strain rate within the context of a recently introduced model that reproduces the crossover. While the chaotic regime has a small set of positive Lyapunov exponents, interestingly, the scaling regime has a power-law distribution of null exponents which also exhibits a power law. The slow-manifo...

We study the crossover behaviors that can be observed in the high-temperature phase of three-dimensional dilute spin systems, using a field-theoretical approach. In particular, for randomly dilute Ising systems we consider the Gaussian-to-random and the pure-Ising-to-random crossover, determining the corresponding crossover functions for the magnetic susceptibility and the correlation length. M...

This paper extends a geometric framework for interpreting crossover and mutation [4] to the case of sequences. This representation is important because it is the link between artificial evolution and biological evolution. We define and theoretically study geometric crossover for sequences under edit distance and show its intimate connection with the biological notion of sequence homology.

In all eukaryotic species examined, meiotic recombination, and crossovers in particular, occur non-randomly along chromosomes. The cause for this non-random distribution remains poorly understood but some specific DNA sequence motifs have been shown to be enriched near crossover hotspots in a number of species. We present analyses using machine learning algorithms to investigate whether DNA mot...

      There are evidences that statins have anti-inflammatory effects beyond their cholesterol lowering properties. The study was conducted to assess the effects of atorvastatin on asthma as an inflammatory disease. Patients with moderate to severe asthma were entered this randomized, double blind, crossover clinical trial. The impact of oral atorvastatin (10 mg/day) on the lung function of nor...

Citation: Linares IMP, Guimaraes FS, Eckeli A, Crippa ACS, Zuardi AW, Souza JDS, Hallak JE and Crippa JAS (2018) No Acute Effects of Cannabidiol on the Sleep-Wake Cycle of Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study. Front. Pharmacol. 9:315. doi: 10.3389/fphar.2018.00315 No Acute Effects of Cannabidiol on the Sleep-Wake Cycle of Healthy Subjects: A Randomiz...