Protein arginine methyl transferase 5 (PRMT5) is a signaling protein and histone modifying enzyme that is important in many cellular processes, including regulation of eukaryotic gene transcription. Reported here is a 3.7 Å structure of PRMT5, solved in complex with regulatory binding subunit MEP50 (methylosome associated protein 50, WDR77, p44), by single particle (SP) cryo-Electron Microscopy...

In this paper we develop a Model Predictive Controller (MPC) for regulation of a cement mill circuit. The MPC uses soft constraints (soft MPC) to robustly address the large uncertainties present in models that can be identified for cement mill circuits. The uncertainties in the linear predictive model of the cement mill circuit stems from large variations and heterogeneities in the feed materia...

Mathematical model of rolling process is used at cold mill rolling on tandem mills in metallurgy. The model goal is to analyse rolling process according to process data measured on the mill and get immeasurable variables necessary for rolling control and optimal mill pre-set for next rolled coil. The values obtained by model are used as references for superimposed technology controllers (thickn...

Andrews's recent proof of the Mills-Robbins-Rumsey conjectured formula for the number of totally symmetric self-complementary plane partitions is used to derive a new multi-variate constant term identity, reminiscent of, but not implied by, Macdonald's BC,-Dyson identity. The method of proof consists in translating to the language of constant terms an expression of Doran for the desired number ...

Around 40% of electricity in the UK is currently generated by coal-fired power stations. Coal-fired power stations nowadays are required to operate more flexibly with more varied coal specifications and regularly use coal with higher volatile contents and biomass materials; this can increase the risks of pressurisation or fires in milling plants. The power stations are also obliged to vary thei...

Generally, crash stops are performed to obtain measurement of charge filling and slurry loading. The crash stop involves running the mill under steady state then cutting off all feed streams to the mill as it is being stopped. Sufficient time is required to obtain all the important measurements correctly during the crash stop. The mill filling should be measured at a minimum of 3 points along t...

Carbon fiber reinforced plastic (CFRP) composite materials have favorable mechanical and physical properties such as low density, high strength-to-weight ratio, fatigue resistance creep behavior, stiffness. Thanks to these unique properties, they produce aircraft parts outer flaps, carry-through structures, center wing boxes automotive body panels, engine components, structure members. However,...

Over the last decade HepaRG cells have emerged as a promising alternative to primary human hepatocytes (PHH) and have been featured in over 300 research publications. Most of these reports employed freshly differentiated HepaRG cells that require time-consuming culture (∼28 days) for full differentiation. Recently, a cryopreserved, predifferentiated format of HepaRG cells (termed here "cryo-Hep...

PURPOSE The arrhythmogenic effect of stem cells transplantation (SCT) in an infarct myocardium is still unknown. We investigated arrhythmogenicity of SCT in rat cryo-infarct model. MATERIALS AND METHODS In rat cryo-infarct model, bone marrow mononuclear stem cells (MNSC, 1 x 10(7) cells) were transplanted into the infarct border zone (BZ) of the LV epicardium. We compared the optical mapping ...

Rhythmically active motor circuits are influenced by neuronally released and circulating hormone modulators, but there are few systems in which the influence of a peptide hormone modulator on a neuronally modulated motor circuit has been determined. We performed such an analysis in the isolated crab stomatogastric nervous system by assessing the influence of the hormone crustacean cardioactive ...