A modular multiphase flow crystallizer set-up for the continuous crystallization of paracetamol with an in-line nuclei generator has been developed. Gas bubbles are introduced in a capillary to provide heterogeneous nucleation sites and enhance rate. Taking advantage separate growth sections, control over crystal size distribution is achieved without compromising its span. Comparison batch show...

Achieving “mixed-product removal” in a mixed-suspension mixed-product removal crystallizer (MSMPRC), operating with pressure-driven suspension transfer, is challenging. In this work, single and multiphase computational fluid dynamics (CFD) simulations were used to guide the choice of suitable withdrawal position, which was found be that an immersed tube close vessel wall. The chosen position th...

Size, shape, and polymorphic form are the critical attributes of crystalline particles and represent the major focus of today's crystallization process design. This work demonstrates how crystal properties can be tuned efficiently in solution via a tubular crystallizer that facilitates rapid temperature cycling. Controlled crystal growth, dissolution, and secondary nucleation allow a precise co...

This paper will introduce, compare and contrast two prototype knowledge systems as it presents a more general framework for thinking about how community of practice and organizational perspectives to knowledge management might be integrated. The first prototype is called the Knowledge Nebula Crystallizer (KNC). The KNC is a demonstration of concept developed at the University of Tokyo. It is us...

In the ice cream industry, the type of final desired product (large cartons (sqrounds) or ice creams on a stick) determine the viscosity at which the ice cream has to be produced. One of the objectives of the ice cream crystallization processes is therefore to produce an ice cream of specified viscosity. In this paper, a nonlinear control strategy is proposed for the control of the viscosity of...

The results of a numerical analysis unsteady heat transfer in the “metal-mold-environment” system during continuous combined casting and extrusion an aluminum alloy installation with horizontal carousel mold are presented. engineering zones characterized by different intensity between melt surface have been determined. A quantitative assessment influence rate heating crystallizer on temperature...

Continuous tubular crystallizers have the potential to reduce manufacturing costs and increase product quality. However, designing is a complex challenging task as crystallization complex, multiphase process with propensity for fouling clogging. While several designs been proposed overcome these issues, are either unproven or poorly scalable complex. In this work continuous crystallizer designe...