The aim of present research was to prepare novel serum stable long circulating polymeric nanoparticles for curcumin with a modification to the well known and novel nanoparticle albumin bound technology. polyethylene glycol-albumin-curcumin nanoparticles were prepared using serum albumin and poly ethylene glycol using desolvation technique. Nanoparticles were characterized for encapsulation effi...

The initial response to treatment and subsequent development of resistance to carboplatin are very important challenges. Use of nano drug delivery is a new method to replace standard chemotherapy. In this research, both non-PEGylated and PEGylated nanoparticles (NPs) were prepared by mini-emulsion polymerization of poly (butyl cyanoacrylate) (PBCA) NPs. Characteristics such as size, polydispers...

From previous studies, it has been found that curcumin exhibits an anti-inflammatory activity and is being used for the treatment of skin disorders; however, it is hydrophobic and has weak penetrating ability, resulting in poor drug transport through the stratum corneum. The aim of this study was to develop liquid crystalline systems for topical administration of curcumin for the treatment of i...

The present research aimed to improve the dissolution rate and bioavailability of curcumin using the potential of liquisolid technology. Twelve drug-loaded liquisolid systems (LS-1 to LS-12) were prepared using different vehicles (PEG 200, PEG 400 and Tween 80) and curcumin concentrations in vehicle (40%, 50%, 60% and 70%, w/w). The carrier [microcrystalline cellulose (MCC) PH102] to coat (Aero...

Objective: Curcumin penetration can be increased by formulating it into the transethosome system. Surfactant is one of components that affect physical properties and vesicles. In this study, a combination two surfactants was used to see effect on curcumin penetration.
 Methods: This study tween 60 span with concentration ratio 0:5 (F1), 1:1 (F2), 2:1 (F3), 1:2 (F4). An evaluation included ...

Diabetic peripheral neuropathy results in diabetic neuropathic pain (DNP). Satellite glial cells (SGCs) enwrap the neuronal soma in the dorsal root ganglia (DRG). The purinergic 2 (P2) Y12 receptor is expressed on SGCs in the DRG. SGC activation plays an important role in the pathogenesis of DNP. Curcumin has anti-inflammatory and antioxidant properties. Because curcumin has poor metabolic stab...

Amphiphilic calix[4]arenes were designed as phospholipid mimics by incorporating PO3H2 or NMe3(+) head groups. Using PC12 cells and three stressors (H2O2, menadione and glutamate), we established safe calix[4]arene levels that are able not only to deliver antioxidant payloads of curcumin, but intriguingly also have inherent antioxidant properties. The calix[4]arenes appear to be potent syntheti...

In this study, curcumin loaded ovalbumin nanoparticles (CONPs) were fabricated at optimized processing conditions and compared with the neat ONPs. The particles characterized for molecular, thermal, antimicrobial, antioxidant properties. particle size values varied from 45.64 nm to 138.14 encapsulation efficiency of CONP was 24%. SEM images indicated that ONPs CONPs had spherical shapes diamete...

Abstract Background A surgical wound is an incision made by a surgeon. Slow healing may lead to chronic wounds which be potential health problem. The aim of this study formulate curcumin-loaded liposomes in lysine–collagen hydrogel for enhancing healing. Curcumin-loaded were prepared using thin-film hydration method. liposomal formulation was characterized analysing its size, morphology, encaps...

Abstract Matrine (MAR), a quinolone alkaloid, was employed to augment the stability of zein nanoparticles. The incorporation MAR into hydrophobic shell nanoparticles primarily achieved through hydrogen bonding. Curcumin (CUR), active substance, encapsulated in core zein/matrine (ZMNPs). preparation ZMNPs and curcumin-loaded (CZMNPs) accomplished using an antisolvent precipitation method. encaps...