Although metastasis from cutaneous malignant melanoma to the small intestine is not uncommon, primary small bowel melanoma (SBM) is extremely rare. This case report describes a rare case of primary SBM, diagnosed by single-balloon enteroscopy. A 74-year-old man presented with recurrent melena. Upper endoscopy and colonoscopy were unremarkable. Abdominal computed tomography (CT) revealed an ilea...

background: malignant melanoma, one of the most deadly skin cancers, is a skin tumor that arises from the epidermal melanocytes. the aim of this study is to evaluate the demographic and clinical data of malignant melanoma patients in a referral dermatology center in the south of iran. methods: in this retrospective study, we have reviewed files of 116 patients diagnosed with malignant melanoma ...

melanoma of the oral cavity is a rare malignant disease. on account of the presence at relatively obscure areas in the oral cavity, most of oral malignant melanomas are diagnosed at a late stage. early diagnosis is essential for successful treatment and perhaps is the key factor in improving the prognosis of oral malignant melanoma. however, no large clinical series exist, and in fact, clinical...

This review deals with difficulties of diagnosis in cutaneous malignant melanoma encountered by histopathologists of variable seniority and is based on referred material at The Royal Marsden Hospital over a 20-year period and on the experience of more than two-and-a-half thousand cases referred to The World Health Organisation Melanoma Unit which I reviewed when chairman of the Pathologists' Co...

The matrix metalloproteinases (MMPs) are implicated in connective tissue destruction during cancer invasion and metastasis. A naturally occurring variant arising from the insertion or deletion of a guanine in the promoter of the MMP-1 gene has recently been reported and shown to influence its transcriptional activity in melanoma cells. In this study, MMP-1 genotype was determined in 139 Caucasi...

INTRODUCTION Although metastatic melanoma has a poor prognosis, cutaneous metastases represent a special case given their ready accessibility, making it possible for dermatologists to apply local treatment. We report our experience with intralesional treatment with interleukin (IL) 2 in 7 patients with cutaneous metastases from malignant melanoma. MATERIAL AND METHODS A total of 244 lesions i...