The use of the FANFT model has facilitated clinical trials which are now beginning to have an impact on the therapy of human bladder tumors. We studied C. parvum and Glucan immunotherapy of FANFT tumors, and demonstrated the enhancement of tumor growth following Glucan administration. Weekly injections of cyclophosphamide (CY) retarded tumor growth and increased survival. Combining C. parvum or...

A 25-year-old woman presenting with progressive muscle weakness in the distal extremities in the absence of sensory involvement for 2 years was diagnosed with multifocal motor neuropathy (MMN). Her disease was difficult to manage with various immunosuppressants, and the muscle weakness eventually progressed to involve the respiratory muscles, necessitating mechanical ventilation. Intravenous cy...

Reactions of [Pt(PCy(3))(2)] (Cy = cyclohexyl) with group 12 metal dihalides have afforded the novel metal only Lewis pair (MOLP) complexes, [(Cy(3)P)(2)Pt→MX(2)] (M = Zn or Cd, X = Br or I), or the oxidative addition product, trans-[(Cy(3)P)(2)(I)PtHgI]. The zinc complex represents the first MOLP to contain an unsupported Pt→Zn linkage.

ETHNOPHARMACOLOGICAL RELEVANCE Aqueous extracts of Cymbopogon citratus (Cy) leaves are used in traditional medicine for the treatment of inflammatory conditions, however, little is known about their mechanism of action. AIM OF THE STUDY The aim of this study is to explore the anti-inflammatory properties of Cymbopogon citratus leaves and their polyphenol-rich fractions (PFs), as well its mech...

We have previously demonstrated an increase in proapoptotic caspase-3 in the kidney of Han:SPRD rats with polycystic kidney disease (PKD). The aim of the present study was to determine the effect of caspase inhibition on tubular cell apoptosis and proliferation, cyst formation, and renal failure in the Han:SPRD rat model of PKD. Heterozygous (Cy/+) and littermate control (+/+) male rats were we...

High-dose cyclophosphamide (Cy) and G-CSF are widely used to mobilize hemopoietic stem cells for treating patients with high-dose chemotherapy and autologous stem cell transplantation (ASCT). Because lymphocyte count in the graft collected after Cy-G-CSF treatment is an independent survival factor after ASCT for patients with multiple myeloma, our purpose was to study how Cy-G-CSF treatment aff...

BACKGROUND Outcomes of haploidentical hematopoietic cell transplantation (haplo-HCT) with post-transplant cyclophosphamide (PT-Cy) have greatly improved. It remains unknown whether haplo-HCT with PT-Cy was associated with poor outcomes when compared with HLA-matched HCT. To address this issue, we performed a meta-analysis to compare outcomes of haplo-HCT with PT-Cy with those of HLA-matched HCT...

Recently, cyclosporin-A (Cy-A) has been used in the treatment of myasthenia gravis (MG). This drug could be employed in some patients refractory to classic treatments or that develop undesirable side effects. It is reported the case of a 22 year-old woman with generalized and severe MG, and diabetes mellitus. She had been submitted to thymectomy and reoperated, to the classic ethiopathogenic me...

Chapter 2 reports two experiments that examine perceptual learning in humans. In Experiment 1, participants received intermixed exposure to two similar compounds (AX, BX, AX, BX ...) and blocked exposure to a second pair of similar compounds (CY, CY... DY, DY...). Aversions established to AX and CY generalized less to BX than to DY. This confirms that intermixed exposure results in greater perc...

Directing protein and energy sources towards lactation is crucial to optimise milk production in sows but how this influences colostrum yield (CY) remains unknown. The aim of this study was to identify associations between CY and the sow's use of nutrient resources. We included 37 sows in the study that were all housed, fed and managed similarly. Parity, back fat change (ΔBF), CY and performanc...