STUDY DESIGN The expression of cyclooxygenase-2 was studied immunohistologically in specimens from lumbar disc herniation. The cultured disc cells also were examined to evaluate the significance of cyclooxygenase-2, which might be involved in the pathogenesis of lumbar disc herniation. OBJECTIVE To investigate whether cyclooxygenase-2 might be involved in the pathogenesis of lumbar disc herni...

Establishing new predictive and prognostic factors in various cancers is an ongoing challenge for many decades. Biomarkers detected in preclinical studies as predictive and prognostic factors could be potential targets for new drug development. Cyclooxygenase enzyme plays a key role in inflammation and has two isozymes synthesized by cyclooxygenase-1 and cyclooxygenase-2 genes. Cyclooxygenase e...

The prostaglandins are lipid mediators, discovered in the 1930s by von Euler in Sweden and Goldblatt in the United Kingdom. They are made by the bifunctional enzyme, cyclooxygenase, which has both cyclooxygenase and peroxidase activities in the same molecule. Prostaglandins are involved in physiological functions such as protection of the stomach mucosa, aggregation of platelets and regulation ...