نتایج جستجو برای: cyclopia

تعداد نتایج: 234  

2014
Marcos Julián Cardozo Luisa Sánchez-Arrones África Sandonis Cristina Sánchez-Camacho Gaia Gestri Stephen W. Wilson Isabel Guerrero Paola Bovolenta

Patterning of the vertebrate optic vesicle into proximal/optic stalk and distal/neural retina involves midline-derived Hedgehog (Hh) signalling, which promotes stalk specification. In the absence of Hh signalling, the stalks are not specified, causing cyclopia. Recent studies showed that the cell adhesion molecule Cdon forms a heteromeric complex with the Hh receptor Patched 1 (Ptc1). This rece...

Journal: :The EMBO Journal 2007
Veronika Sander Bruno Reversade E M De Robertis

We present a loss-of-function study using antisense morpholino (MO) reagents for the organizer-specific gene Goosecoid (Gsc) and the ventral genes Vent1 and Vent2. Unlike in the mouse Gsc is required in Xenopus for mesodermal patterning during gastrulation, causing phenotypes ranging from reduction of head structures-including cyclopia and holoprosencephaly-to expansion of ventral tissues in MO...

Journal: :The Journal of biological chemistry 2009
Hernán Alonso Michelle J Blayney Jennifer L Beck Spencer M Whitney

Like many enzymes, the biogenesis of the multi-subunit CO(2)-fixing enzyme ribulose-1,5-bisphosphate (RuBP) carboxylase/oxygenase (Rubisco) in different organisms requires molecular chaperones. When expressed in Escherichia coli, the large (L) subunits of the Rubisco from the archaeabacterium Methanococcoides burtonii assemble into functional dimers (L(2)). However, further assembly into pentam...

Journal: :American Journal of Medical Genetics Part C: Seminars in Medical Genetics 2010

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