The standard treatment for prostate cancer (PCa) is androgen deprivation therapy (ADT) that blocks transcriptional activity of androgen receptor (AR). However, ADT invariably leads to the development of castration-resistant PCa (CRPC) with restored activity of AR. CRPC can be further treated with CYP17 inhibitors to block androgen synthesis pathways, but most patients still relapse after a year...

BACKGROUND Studies have shown that alterations of steroid hormone metabolism, particularly involving testosterone, affect the risk of prostate cancer. Therefore, genetic variation in genes of enzymes which are involved could be of importance. The gene most interest is CYP17, whose enzyme product has an essential role in testosterone hormone synthesis. Some studies have indicated that the A2 all...

The cytochrome P450c17-I (CYP17-I) is one of the enzymes critical to gonadal development and the synthesis of androgens. Two single nucleotide polymorphisms (SNPs) were detected within the coding region of the CYP17-I gene in a population of 75 male Japanese flounder (Paralichthys olivaceus). They were SNP1 (c.C445T) located in exon2 and SNP2 (c.T980C (p.Phe307Leu)) located in exon5. Four physi...

Introduction Long-term differences in steroid hormone levels between women likely contribute to the interindividual variation in ovarian cancer risk, although the precise biological mechanisms are unclear (1). The P450c17a (CYP17) gene codes for 17ahydroxylase and 17,20 lyase which catalyze the rate-limiting step in androgen biosynthesis, cleaving the C21 steroids to the C19 steroids, androsten...

Thiazolidinediones (TZDs) such as pioglitazone and rosiglitazone are widely used as insulin sensitizers in the treatment of type 2 diabetes. In diabetic women with polycystic ovary syndrome, treatment with pioglitazone or rosiglitazone improves insulin resistance and hyperandrogenism, but the mechanism by which TZDs down-regulate androgen production is unknown. Androgens are synthesized in the ...

Expert’s summary: Abiraterone acetate, a small molecule inhibitor of cytochrome P17 (CYP17), inhibits 17 alpha-hydroxylase and C17, 20 lyase, both key enzymes in androgen synthesis. It was tested in 21 chemotherapy-naı̈ve men with metastatic prostate cancer that was resistant to multiple hormone therapies. Once-daily oral abiraterone acetatewas given at doses of 250 mg, 500 mg, 750 mg, 1000 mg, ...