INTRODUCTION: 5-HT2A receptors are of significant clinical interest because of their potential involvement in mediating a variety of physiological functions, including platelet aggregation, thrombus formation, coronary artery spasm, vascular smooth muscle contraction, appetite, sleep, cognition, perception, mood, and other central nervous system functions. Different antagonists such as ketanser...

Objective: To report a case of serotonin syndrome, with episodic worsening course, which responded to treatment with cyproheptadine. Case Report: A 56 year old male, was diagnosed as a case of bipolar affective disorder, hypertension and generalized seizure disorder. While receiving a combination of lithium carbonate 750 mg/d, amlodipine 10 mg/d, phenytoin 300mg/d, sertraline 100 mg/d, trazodon...

INTRODUCTION Calotropis procera is known to produce contact dermatitis and the latex of this plant produces intense inflammation when injected locally. However, the precise mode of its pro-inflammatory effect is not known. In present study we have pharmacologically characterized the inflammation induced by latex of C. procera in a rat paw edema model and determined the role of histamine in late...

Acute pancreatitis was induced in mice by feeding with a choline-deficient ethionine-supplemented diet. All the mice developed acute pancreatitis, and approximately 80% of them died within 4 days. Stereomicroscopic and light microscopic examinations revealed that pancreatic necrosis and circulatory disturbance that were not apparent on day 1 were increased markedly on days 2 and 3. Serum levels...

In the present study we have utilized the Allium cepa root tip meristem model to evaluate the cytotoxic and anti-mitotic activities of latex of Calotropis procera (DL) and podophyllotoxin. Standard cytotoxic drug cyclophosphamide and non-cytotoxic drugs cyprohcptadine and aspirin served as controls. Like cyclophosphamide, both DL and podophyllotoxin significantly inhibited the growth of roots a...

Teucrium polium is used for treatment of visceral pain in Iranian folkloric medicine. In this studyantinociceptive mechanisms of T. polium hydroethanolic extract were examined by acetic acid-inducedwrithing test as a model of visceral pain in male NMRI mice. To reveal the antinociceptive mechanisms ofthe extract, we examined the effects of opioidergic, serotonergic, adrenergic and histaminergic...

Introduction: Feverfew (Tanacetum parthenium) (T.p.) is widely used in folk medicine to treat many diseases. We reported the analgesic effect of T.p. flower and leaf previously. Present study is designed to find the mechanism underlying the anti-nociceptive effect of the aqueous extract of T.p. flower. Method: Based on our previous study, the dose 50 mg/kg i.p. of the T.p. aqueous extract had...

Delayed ejaculation (DE) is an uncommon and a challenging disorder to treat. It is often quite concerning to patients and it can affect psychosocial well-being. Here we reviewed how DE is treated pharmacologically .We also highlighted specific settings where drugs could be introduced to medical practice. Electronic databases were searched from 1966 to February 2016, including PubMed MEDLINE, EM...