Genome mining and biochemical analyses have shown that Leishmania major possesses two pathways for cysteine synthesis--the de novo biosynthesis pathway comprising SAT (serine acetyltransferase) and CS (cysteine synthase) and the RTS (reverse trans-sulfuration) pathway comprising CBS (cystathionine beta-synthase) and CGL (cystathionine gamma-lyase). The LmjCS (L. major CS) is similar to the type...

2-Amino-4-chloro-5-(-nitrophenylsulfinyl)pentanoic acid (1) has been synthesized and shown to induce mechanism-based inactivation of two pyridoxal phosphate dependent enzymes: (1 ) cystathionine y-synthetase, which catalyzes a y-replacement reaction in bacterial methionine biosynthesis; and (2) methionine y-lyase, which catalyzes a y-elimination reaction in bacterial methionine breakdown. The i...

objective(s):  this study was undertaken to investigate the protective effects of vitamin b6, cofactor for cystathionine-γ lyase and cystathionine-β synthase (producers of h2s), alone and in combination with l-cysteine, h2s precursor, on indomethacin-, and ethanol-induced gastric lesions in male nmri mice. materials and methods: fasted male nmri mice were randomly assigned into 12 groups (7 in ...