The thioethers, S-(4-amino-2,4-dicarboxybutyl)cysteamine, S-(4-amino-2,4dicarboxybutyl)cysteine and S-(4-amino-2,4-dicarboxybuty’)glutathione, were synthesized by a Michael addition between 4-methyleneglutamic acid and the respective thiol. In dilute aqueous solution, the reactions exhibit second order kinetics; glutathione reacts much slower than cysteine or cysteamine. The adducts were charac...

research advances during recent years offer new insight into therapy and the prevention of gastrointestinal ulcers by using medicinal plants. flavonoids, tannins, triterpenoids, fatty acids and essential oils are among the most effective herbal constituents that have potential antiulcerogenic properties, and most of them could be found in zataria multiflora. z. multiflora is one of the indigeno...

Extracellular population responses are largely preferred for the study of long-term potentiation (LTP). The effect of Mg2+-free medium on changes in activity and plasticity of Schaffer collateral-CA1 pyramidal cell synapses was examined. Hippcampal slices from cysteamine-treated (200 mg/kg, s.c.) and saline-injected (1 ml/kg, s.c.) albino rats were perfused with ACSF. Population spikes (PS) wer...

Extracellular population responses are largely preferred for the study of long-term potentiation (LTP). The effect of Mg2+-free medium on changes in activity and plasticity of Schaffer collateral-CA1 pyramidal cell synapses was examined. Hippcampal slices from cysteamine-treated (200 mg/kg, s.c.) and saline-injected (1 ml/kg, s.c.) albino rats were perfused with ACSF. Population spikes (PS) wer...

Background: This study examined the effect of including one of two growth factors (100 ng/ml IGF-1 or 20 ng/ ml EGF) in combination with one of two antioxidants (50 μM cysteamine or 50 μM beta-mercaptoethanol) in invitro maturation of buffalo oocytes, followed by fertilization and subsequent development of embryos. Materials and Methods: The oocytes were recovered by in vivo ovum pick-up techni...

Cataract in the developing chick embryo can be easily produced by administration of high doses of glucocorticoid and the cataract is preceded by a decreased level of glutathione in the lens (Nishigori et al, Exp Eye Res 36:617, 1983). In an attempt to prevent cataract formation, various natural and synthetic sulfhydryl compounds, glutathione, cysteine, ergothioneine, penicillamine, cysteamine a...

Cystic fibrosis (CF) is a lethal monogenic disease with mortality and morbidity mostly associated to lung destruction (O'Sullivan and Freedman, 2009). This, in turn, is strictly dependent on recurrent pulmonary infections, with bacteria growing also in biofilms, leading to an unsatisfactory effect of antibiotics (Ratjen and Döring, 2003). The CF registry of patients reports an improvement of bo...