BACKGROUND Intracellular components, such as nucleosomal DNA and cytokeratins, are released from cells during apoptosis, which occurs spontaneously in elevated amounts in patients with various tumors, as well as during treatment with chemotherapeutic drugs. PATIENTS AND METHODS Sera of 30 patients with colorectal cancer, stage Dukes' B to D, who received adjuvant (N=15) or palliative (N=15) c...

INTRODUCTION Lung cancer is one of the most lethal malignancies; however, no serum marker has been routinely recommended until now. METHODS THIS IS A PROSPECTIVE CASE CONTROL STUDY INCLUDING TWO GROUPS OF PATIENTS: Group I-patients with advanced lung cancer and Group II-patients with benign lung disease as control. Serum cytokeratin 19 (CK19) fragment levels were measured at baseline by real-...

PURPOSE The roles of circulating tumor cells (CTCs) as predictive and prognostic factors, as well as key mediators in the metastatic cascade, have been investigated. This study aimed to validate a method to quantify CTCs in peripheral blood using a real-time reverse transcriptase polymerase chain reaction (RT-PCR) assay for cytokeratin (CK)-19 and to evaluate the utility of this assay in detect...

Okadaic acid, dinophysistoxin-1 (35-methylokadaic acid), and calyculin A are potent tumor promoters on mouse skin (H. Fujiki, M. Suganuma, S. Nishiwaki, S. Yoshizawa, J. Yatsunami, R. Matsushima, H. Furuya, S. Okabe, S. Matsunaga, and T. Sugimura. In: R. D'Amato, T. J. Slaga, W. Farland, and C. Henry (eds.), Relevance of Animal Studies to the Evaluation of Human Cancer Risk, pp. 337-350. New Yo...

BACKGROUND This study focused on the association between preoperative serum carcinoembryonic antigen (CEA) and cytokeratin 19 fragment (Cyfra 21-1) levels and pathologic parameters in patients with resected non-small-cell lung cancer (NSCLC). MATERIALS AND METHODS The records of 527 patients who underwent pulmonary resection of NSCLC were reviewed. The association between preoperative serum C...

Cytokeratin 19 (CK19) is one of the most frequently studied immunohistochemical markers in thyroid pathology. The results of several studies suggest that CK19 may be useful in the diagnosis of papillary carcinoma, where it has been shown to have strong diffuse cytoplasmic reactivity. However, the published results vary, and the utility of CK19 in the diagnosis of thyroid lesions is controversia...

Wereport two cases of diffuse malignant pleural mesothelioma occurring almost simultaneously in one family. Patient 1 was a 42-year-old Japanese man who had worked as an electrical engineer for 25 years. Patient 2, his mother, was 69 years old. She lived for 10 years with patient 1 after he started his work, and also worked at a shipyard herself for 6 years. The concentrations of cytokeratin su...

Okadaic acid, dinophysistoxin-1 (35-methylokadaic acid), and calyculin A are potent tumor promoters on mouse skin (H. Fujiki, M. Suganuma, S. Nishiwaki, S. Yoshizawa, J. Yatsunami, R. Matsushima, H. Furuya, S. Okabe, S. Matsunaga, and T. Sugimura. In: R. D'Amato, T. J. Slaga, W. Farland, and C. Henry (eds.), Relevance of Animal Studies to the Evaluation of Human Cancer Risk, pp. 337-350. New Yo...

During meiotic maturation, the cortical cytokeratin filament system of the Xenopus oocyte disappears (Klymkowsky, M. W., and L. A. Maynell. 1989. Dev. Biol. 134:479). Here we demonstrate that this disappearance results from the severing of cytokeratin filaments into a heterogenous population of oligomers, with S- values ranging from 12S and greater. Cytokeratin filament severing correlates with...

FLC shows immunohistochemical features of both hepatocytic and biliary differentiation and is most likely derived from a bipotential cell. A recent study examining 26 cases of FLC and 62 cases of classical HCC by immunohistochemistry showed that both tumor types stained uniformly positively with HepPar1 and most showed a canalicular staining pattern for pCEA confirming hepatocytic differentiati...