aggressive osteoblastoma (ao) is a benign osteoblastic tumor which is rare in the head and neck region. clinical and histological features are therefore overlap with other benign and low-grade malignant tumors. the aim of this article is to report and discuss the differential diagnosis of an aggressive osteoblastoma in the mandible. a 25-year-old male patient reported with pain and asymmetry on...

In humans and canines, the morphology of granulosa cell tumors is extremely variable and causes diagnostic difficulties. In human pathology, immunohistochemistry has been widely used for the diagnosis of granulosa cell tumors, whereas, limited studies are present in canine species. The aim of this study was to investigate the expression of cytokeratins, vimentin, and inhibin-alpha in canine nor...

We report 2 cases of cytokeratin-20 negative neuroendocrine tumors with skin involvement that were not Merkel cell carcinoma. Patient 1. Patient 1 was a 72-year-old man with 3 asymptomatic papular, erythematous lesions measuring 2 to 3 mm in the right paranasal region (Fig. 1). The lesions had appeared 20 days earlier. One of the lesions was excised to reveal a diffuse epithelial tumor consisti...

Circulating tumor cells (CTCs) are important targets for treatment and critical surrogate markers when evaluating cancer prognosis and therapeutic response. A sensitive methodology for detecting CTCs in gastric cancer (GC) patients is needed. In this study we demonstrate a device for enrichment and cultivation of CTCs. In total, 22 patients with GC, all candidates for surgery, were enrolled in ...

Reactive urothelial atypia (RUA) can be difficult to differentiate from dysplastic urothelium. The goal was to evaluate the efficacy of cytokeratin 20 (CK20), Ki-67 and E-cadherin (E-Cad) in this regard. Fifty carcinoma in situ (CIS) cases, 50 non-neoplastic urothelia (25 normal, 25 reactive urothelial atypia (RUA)) and 17 atypia of unknown significance (AUS) cases were evaluated. All cases wer...