AIMS AND BACKGROUND The optimal salvage therapy for recurrent ovarian carcinoma has not been clearly established. Response to second-line chemotherapy is low, with a short median survival (8.8-15 months). We investigated the effect of an aggressive approach consisting of surgery followed by intraperitoneal drug delivery and local hyperthermia. PATIENTS AND METHODS In a phase II clinical study...

Despite optimal treatment (complete cytoreduction and adjuvant chemotherapy), 5-year survival for advanced ovarian cancer is approximately 30% and most patients succumb to their disease. Cytoreductive surgery is accepted as a major treatment of primary ovarian cancer but its role in recurrent disease is controversial and remains a field of discussion mainly owing to missing data from prospectiv...

Background: To present our preliminary surgical experience with cytoreductive radical prostatectomy for patients with oligometastatic prostate cancer. Methods: Ten selective cases with oligometastatic prostate cancer diagnosed by bone scan and biopsy of prostate underwent cytoreductive radical prostatectomy. The operating time, estimated blood loss and perioperative complication were recorded a...

Maximal cytoreductive surgery is an important prognostic factor in advanced epithelial ovarian cancer (EOC). To achieve maximal surgery, en bloc pelvic resection with rectosigmoid colectomy can be effective surgical strategy. This methodology was first described 1968 as radical oophorectomy. Since then, it has been adopted by many medical institutions around the world, and its safety shown stud...

The management and the outcome of peritoneal metastases or recurrence from epithelial ovarian cancer are presented. The biology and the diagnostic tools of EOC peritoneal metastasis with a comprehensive approach and the most recent literatures data are discussed. The definition and the role of surgery and chemotherapy are presented in order to focuse on the controversial points. Finally, the pa...

BACKGROUND Surgical management of advanced-stage ovarian cancer (ASOC) can require diaphragmatic surgery (DS) to achieve complete cytoreduction. The aim of this study was to evaluate modalities and morbidities of DS at the time of initial surgery (INS) and interval debulking surgery (IDS; performed after neoadjuvant chemotherapy). STUDY DESIGN Retrospective review of patients undergoing (unil...

Ovarian cancer is the fifth most common cancer in women, and the most lethal gynecologic malignancy in western countries. Approximately 70% of malignant ovarian cancers are diagnosed with diffuse intraperitoneal spread. The treatment algorithm for ovarian cancer consists of the combination of maximal cytoreductive surgery and chemotherapy [1]. Advanced stages, requiring major tumor debulk ing, ...