it has been reported that several conifers possess cytotoxic activities on some human tumor cell lines. taxol as a natural cytotoxic compound has been extracted from this family. in a program to screen the cytotoxic effects of natural resources, male and female branchlets, fruit or bark of two different species of iranian conifers were collected, identified and the cytotoxic effects of their hy...

background: essential oils are found to have multiple active components which can show in vitro cytotoxic action against various cancerous cell lines. this study reports the in vitro cytotoxic effects of the essential oil from artemisia absinthium l. (asteraceae) growing wild in iran. methods: water-distilled essential oil of a. absinthium collected from ardabil, north-western iran, was examine...

background: rosa damascena is a traditional medicinal plant used in asia to treat several ailments. this study reports in vitro and in vivo antioxidative properties and toxicity of methanolic and aqueous extracts of white rose, an indigenous variety of rosa damascena from iran. methods: the antimicrobial activities, total phenolics, antioxidative properties and the blood sera ferric-reducing an...

abstract: peganum harmala l. (zygophylaceae) has been used in a variety of practical applications in medical science. our objective in the current study was to determine the effects of the seed extract on herpes simplex virus type 1 (hsv-1) replication in vero cells. different concentrations (100, 500, 571, 667, 800 and 1000 µg/ml) of the extract were examined. experiments were carried out usin...

exploration of natural products with antitumoral effects such as etoposide, tenioposide, camptothecin and paclitaxel from conifers provoked us to do some research on anti-tumoral activity of iranian medicinal plants. ten different species of iranian conifers aerial parts were collected across the country. the relative potency of methanolic extract were investigated on the inhibition of topoisom...

abstract: background and aim: resin cements are used widely in restorative dentistry regardless of their biocompatibility. the aim of this study was to compare the cytotoxicity of two categories of dental cements consisting of three chemically set cements (fuji i, fuji plus and harvard) and two dual curing cements (biscem and duo-link) by use of mtt assay. materials and methods: in this experim...

iran has 1260 km of coastline that borders the persian gulf and the oman sea in the northwest indian ocean. marine algae are one of the natural resources in the marine ecosystem which produce a wide range of new secondary metabolites with various biological activities that play an important role in the pharmaceutical care. in this study the cytotoxic activity of 28 marine algae of chabahar coas...

chromanone derivatives demonstrate remarkable cytotoxity against a varieties of cancer cell lines. novel 9-[hydroxy(substitutedphenyl)methyl]-2,2-dimethyl-2,3,8,9- tetrahydro-4h,10h-pyrano[2,3-f]chromene-4,10-diones as glyasperin analogues were synthesized in four steps from known 4-chromone 1. the key step was the preparation of chromane dione 5a by regioselective intramolecular cyclization re...

background and objectives: dried pulps and peels of ziziphus jujuba fruits are commonly applied as food because of their high nutritional value. it has been widely used in traditional medicine as laxative, tonic, wound healing agent and appetizer. the aim of this study was to evaluate the anti-melanogenic effects of z. jujuba fruit. methods: fruit extracts were obtained by two different extract...

By discovering how chemical compounds/xenobiotics cytotoxicity is affected when their metabolic pathways are inhibited or activated, the metabolic pathways that activate versus detoxify chemical compound can be identified. Reactive metabolites contributing to cytotoxicity can also be identified. In this lecture, the pretreatment of inhibitors and activators of xenobiotic metabolizing enzymes as...