Background: Pruritus is one of the most disabling problems in patients with chronic renal failure. It is a distressing symptom with a negative impact on quality of life and is also very frustrating for both patients and their physicians. The pathophysiological mechanisms of pruritus are mainly unknown. The aim of this study was to identify factors associated with pruritus in these patients. Met...

Background: Pruritus is one of the commonest frustrating manifestations in chronic renal failure. The exact cause of uremic pruritus is unknown and several factors are reported to be involved in its pathogenesis, the most important of which are abnormalities in calcium and phosphorus metabolism. Broad band UVB phototherapy plays an important role in treatment of uremic pruritus through differen...

background uremic pruritus is a common and bothersome complaint among end-stage renal disease which affect between 25% and 60% of this population .but there is no decisive cure for treatment of it. in this study, the effects of omega-3 for treatment of pruritus were investigated in hemodialysis patients. methods a double-blind randomized study was carried out in the form of placebo-controlled c...

BACKGROUND Pruritus affects many haemodialysis (HD) patients. In this study, pruritus and its relationship to morbidity, mortality, quality of life (QoL), sleep quality and patient laboratory measures were analysed in >300 dialysis units in 12 countries. METHODS Pruritus data were collected from 18 801 HD patients in the Dialysis Outcomes and Practice Patterns Study (DOPPS) (1996-2004). Analy...

Discovery of pruritus-specific mediators and receptors facilitated the neurobiological concept of pruritus: itch-specific (histamine-dependent and histamine-independent C-fibers); itch-specific receptors on cutaneous and spinal neurons; "dialogue" between the pruritus-specific neurons and cells in the skin; peripheral and central mediation of pruritus; functional "pruritus-specific matrix" in t...

/doi/10.1111/j.1529-8019.2008.00167.x/abstract) Article References (/doi/10.1111/j.1529-8019.2008.00167.x/references) Cited By (/doi/10.1111/j.1529-8019.2008.00167.x/citedby) Get PDF (116K) (/doi/10.1111/j.1529-8019.2008.00167.x/pdf)

BACKGROUND Several studies have been performed to evaluate the efficacy of dietary n-3 fatty acid for patients with renal dysfunction. While about 40% to 80% of patients with end-stage renal disease (ESRD) complain about pruritus and xerosis, there are few reports on the effects of topical n-3 fatty acid on these symptoms. OBJECTIVE In order to investigate the possible beneficial effects of t...