PURPOSE We examined the effects of creatine supplementation on the response to repeated bouts of resistance exercise. METHODS Young men (24.1 ± 5.2 yr) were divided into Creatine (CM, n = 9) and Placebo (PL, n = 9) groups. On day (D) 1 and D15, subjects performed four sets of bicep curls at 75% 1-RM to concentric failure. On D8-D13, subjects consumed either 20g/d creatine monohydrate or place...

Bin toxin from Bacillus sphaericus acts on Culex quinquefasciatus larvae by binding to Cqm1 midgut-bound receptors, and disruption of the cqm1 gene is the major cause of resistance. The goal of this work was to screen for a laboratory-selected resistance cqm1(REC) allele in field populations in the city of Recife, Brazil, and to describe other resistance-associated polymorphisms in the cqm1 gen...

Objective: Osteoarthritis (OA) is a common disease characterized by progressive degeneration of articular cartilage. Several studies have been performed to evaluate the association between asporin gene aspartic acid repeat (ASPN D-Repeat) polymorphism and osteoarthritis susceptibility, but produced conflicting results. Our aim is to determine whether ASPN D-repeat polymorphism is associated wit...

The mechanisms that regulate the induction of term or preterm delivery (PTD) are not fully understood. Infection is known to play a role in the induction of pro-inflammatory cascades in uteroplacental tissues associated with preterm pathological parturition. Similar but not identical cascades are evident in term labour. In the current study, we used a mouse model to evaluate the role of prokine...

Introduction. Bond strength between dissimilar materials is the most important characteristic of laminated composites, which determines success its development for industrial use. In order to develop theory joining by plastic deformation, it proposed perform computer simulation joint deformation representative volumes on a microscale and compare parameters stress-strain state with previously pr...

Introduction: This study aimed to evaluate and compare the apical sealing ability of different irrigation regimens (NaOCl, CHX, NS, and MTAD) . Methods: Seventy intact extracted single-rooted human teeth were selected. The roots were resected at 3 mm short of the apical foramen after access preparation. The canals were prepared with profile. This rotary file moved forward into the apical for...

BACKGROUND Features of life history are subject to environmental regulation in the service of reproductive fitness goals. We have previously shown that the infant-to-childhood transition reflects the adaptive adjustment of an individual's size to the prevailing and anticipated environment. METHODS To evaluate effects of weaning age on life-history traits in rats, we repeatedly measured length...

The neural cell adhesion molecules (N-CAM) occur chiefly in two molecular forms that are selectively expressed at various stages of development. Highly sialylated forms prevalent in embryonic and neonatal brain are gradually replaced by less sialylated forms as development proceeds. Here we describe a monoclonal antibody raised against the capsular polysaccharides of meningococcus group B (Men ...

Lithium stimulated corticotropin (ACTH) secretion by mouse pituitary tumor cells (AtT-20/D16-16) and by normal rat anterior pituitary cells in primary culture. Effects were observed at less than 2 mM LiCl. ACTH secretion was comparable in magnitude to that induced by other secretagogues, was calcium dependent, and was inhibited by somatostatin. Lithium also induced changes in [3H]inositide meta...

The ability of corticotropin releasing factor (CRF) to stimulate adrenocorticotropin (ACTH) synthesis in corticotrophs was assessed by measuring total cell content of ACTH and the levels of proopiomelanocortin (POMC) mRNA in a cloned tumor cell line of the mouse anterior pituitary (AtT-20/D16-16). CRF treatment caused a time-dependent increase in POMC mRNA levels (measured using a hybridization...