A DABCO-catalyzed highly regio- and stereoselective syn-1,4-bromolactonization of conjugated enynes was discovered. The 1,4-addition occurred selectively over 1,2-addition for most enynes. In contrast to anti 1,2-addition to alkenes, where two adjacent stereogenic centers are created, 1,4-addition across conjugated enynes can produce a stereogenic center and an axially chiral allene simultaneou...

Significance: This paper describes the palladiumcatalyzed enantioselective aza-Morita–Baylis–Hillman reaction of acrylonitriles with imines. The bulky pincer ligand enabled the synthesis of enantioenriched α-methylene-β-aminonitriles in high yield. Comment: The palladium–pincer complex preferably activates acrylonitrile, even in the presence of ethyl acrylate. The palladium ketenimide is a key ...

Authors The Canadian Chiropractic Association and the Canadian Federation of Chiropractic Regulatory Boards, Clinical Practice Guidelines Development Initiative (The CCA•CFCRB-CPG), Guidelines Development Committee (GDC) comprising: Elizabeth Anderson-Peacock, BSc, DC (Barrie, ON); Roland Bryans, BA, DC, Cochair (Clarenville, NL); Normand Danis, DC, Co-chair (Montreal, QC); Andrea Furlan, MD (E...

2-(2-Chloroaroyl)methyleneimidazolidines with four reactive sites show fascinating structural features and could be used as a new strategy for the synthesis of novel heterocycles. This paper presents our new findings in the reaction of 2-(2-chloroaroyl)methyleneimidazolidines with allenic esters affording functionalized imidazo(pyrido)[1,2-a]pyridines via DABCO-catalyzed tandem annulations. Of ...

Amides are one of the most important functional groups in organic chemistry and play essential roles both pharmaceutical industry life sciences. However, due to natural reactivity carboxylic acids amines, their direct coupling is challenging often leads reactions that not atom-economic produce large amounts non-recoverable by-products. Despite impressive number reagents available, sustainable m...

A series of azobenzene-loaded metal-organic frameworks were synthesized with the general formula M2(BDC)2(DABCO)(AB)x (M = Zn, Co, Ni, and Cu; BDC 1,4-benzenedicarboxylate; DABCO 1,4-diazabicyclo[2.2.2]octane; AB azobenzene), herein named M-1?ABx. Upon occlusion AB, each framework undergoes guest-induced breathing, whereby pores contract around molecules forming a narrow-pore (np) framework. Th...