This document is part of the Air Technical Index [ATI] collection. The ATI collection is over 50 years old and was imaged from roll film. The collection has deteriorated over time and is in poor condition. DTIC has reproduced the best available copy utilizing the most current imaging technology. ATI documents that are partially legible have been included in the DTIC collection due to their hist...

Until the late eighties, the only treatment available for uveal melanoma was enucleation of the affected eye, though brachytherapy, thermotherapy and radiation therapy can be used to treat small/medium size tumours with preservation of the eye [16]. Several different chemotherapeutic agents have been used, such as Dacarbazine, alone or in combination with Interferonalpha 2b, after primary treat...

In Poland, morbidity and mortality rates for melanoma are constantly increasing. In the case of inoperable disease or distant metastases, prognosis remains poor. For many years, dacarbazine has been the gold standard in systemic treatment. Recently, a significant progress in melanoma therapy has been observed. Introducing targeted therapy or immunotherapy significantly improved treatment outcom...

Dacarbazine (DTIC) is commonly used for the treatment of malignant melanoma and Hodgkin's disease. A very rare complication of this cytotoxic agent is acute vascular hepatic damage, e.g. veno-occlusive disease or Budd-Chiari syndrome. The pathophysiological mechanism involved seems to be an immune reaction. This complication is frequently fatal. We report a patient who developed severe hepatic ...

This is a remarkable time for melanoma research and treatment. Before this year, approved agents available for the treatment of metastatic melanoma were limited to dacarbazine (DTIC) and interleukin-2 (IL-2), with benefits achieved in only a small minority of patients treated with either drug. In 2011, however, two new agents, ipilimumab (YervoyTM) and vemurafenib (ZelborafTM), were approved, w...