Objectives 1. Describe different combinations of normal and abnormal hemoglobins and their phenotypic expression 2. Describe the pathophysiology of vasooclusion secondary to hemoglobinopathies 3. Define and describe hand-foot syndrome 4. Describe features of osteomyelitis secondary to sickle cell disease and its differentiation from bone infarct 5. Describe features of avascular necrosis of bon...

Imaging of psoriatic arthritis (PsA) is important for two reasons: the differential diagnosis from other arthritides and the assessment of structural damage that can be inhibited by the new drugs such as the anti-TNFalpha agents. Plain film radiographic findings of peripheral arthritis have been important in elaborating the concept of PsA as a separate disease entity. Characteristic aspects of ...

Acrodermatitis continua of Hallopeau (ACH) is a rare variant acral pustular psoriasis, exclusively involving the distal phalanges and nails hands feet. We herein report case concurrent ACH psoriatic arthritis sine psoriasis presenting with dactylitis. The patient was successfully treated biologics apremilast.

Background: Power Doppler ultrasonography is a sensitive imaging tool to assess synovitis in psoriatic arthritis (PsA). 1,2 ULTIMATE ( NCT02662985 ) the first large, randomised, double-blind placebo-controlled phase IIIb study PsA, using ultrasound evaluate early response secukinumab on synovitis. The use of standardised and reliable global EULAR-OMERACT composite score at patient level (GLOESS...

Objectives: This study aims to evaluate clinical responses in patients with active psoriatic arthritis who, despite secukinumab 300 mg subcutaneous monthly, are switched ixekizumab 80 every four weeks. Methods: We conducted a chart review of adult treated at one center. identified all inflammatory who were from ixekizumab. Baseline demographics such as disease duration, age, gender, number prev...

INTRODUCTION Psoriatic arthritis (PsA) is a distinctive inflammatory arthritis which may typically develop in a subgroup of individuals suffering from psoriasis. We recently described progranulin autoantibodies (PGRN-Abs) in the sera of patients with different autoimmune diseases including seronegative polyarthritis. In the present study we investigated the occurrence of PGRN-Abs in PsA. METH...

OBJECTIVES To screen susceptibility loci for ankylosing spondylitis (AS) using an affected-only linkage analysis based on high-density single nucleotide polymorphisms (SNPs) in a genome-wide manner. PATIENTS AND METHODS AS patients from ten families with Cantonese origin of China were enrolled in the study. Blood samples were genotyped using genomic DNA derived from peripheral blood leukocyte...