BACKGROUND Many women with migraine experience a change in migraine frequency associated with the menstrual cycle. This study was undertaken to study the effect of vitamin E as a prophylactic agent on women with menstrual migraine. MATERIAL/METHOD During a placebo-controlled double-blinded trial, 72 women with menstrual migraine received placebo (identical in appearance to vitamin E) daily fo...

This 24-week, open-label, Phase Ib, parallel-arm, multiple-dose trial assessed the pharmacokinetics, safety and tolerability of a once-monthly injection of aripiprazole (aripiprazole once-monthly) in 41 subjects with schizophrenia. The objective was to determine if aripiprazole plasma concentrations (at doses of 200, 300 and 400mg) were within the therapeutic range observed for the oral tablet ...

BACKGROUND Reducing bisphosphonate dosing frequency may improve suboptimal adherence to treatment and therefore therapeutic outcomes in postmenopausal osteoporosis. Once-monthly oral ibandronate has been developed to overcome this problem. OBJECTIVE To confirm the 1 year results and provide more extensive safety and tolerability information for once-monthly dosing by a 2 year analysis. METH...

Okinawa is located in a subtropical area and is well-known for low mortality due to ischemic heart disease (IH-D) and cerebrovascular disease (CVD). However, the factors that contribute to these low mortality rates remain unclear. We examined the seasonal variation in the mortality due to IHD and CVD among Okinawa and Osaka residents, aged 45 to 84 years, between 1992 and 1996. In addition, we ...

Cryospheric and ecological studies become very complicated due to the absence of observed data, particularly in mountainous regions Central Asia. Performance analysis Satellite-Based Precipitation Datasets (SBPD) is critical before their direct hydro-climatic applications. This study assessed ground validation four SBPDs (IMERG, TRMM, PERSIANN-CDR, PERSIANN-CSS). From January 2000 December 2013...

one of the most important hydrological time series task is to determine if there is any trend in the data and how to achieve stationarity when there is nonstationarity behavior in data. detecting trend and stationarity in hydrological time series may help us to understand the possible links between hydrological processes and global climate changes. in this study yearly, monthly and daily stream...

Although satellites provide reliable and repeated measurements on a global basis, particulate matter air quality information can be derived from satellites only when clouds are absent and when surface conditions are favorable. However, ground measurements provide particulate matter information irrespective of cloud cover and surface conditions. Therefore there could be a sampling bias when usin...

Estuaries significantly impact the global carbon cycle by regulating the exchange of organic matter, primarily in the form of dissolved organic carbon (DOC), between terrestrial and marine carbon pools. Estuarine DOC dynamics are complex as tides and other hydrological and climatic drivers can affect carbon fluxes on short and long time scales. While estuarine and coastal DOC dynamics have been...

in agricultural practices, reference evapotranspiration (et0) parameters need to be specified for crop water requirement determination. although, the crop water requirement is not an easy task. numerous mathematical models and experimental methods have been developed for this purpose in the entire world. on the other hand, ten-daily and monthly average meteorological data are used in many of ir...