Experiments were performed to determine if differences in porphyrin photosensitivity could be observed for cells with varying efficiency in DNA damage repair, as well as for cells which make up components of the vasculature. Photofrin II is undergoing current clinical evaluation for photodynamic therapy of solid tumors, and therefore the retention, dark toxicity, and photosensitizing effects of...

This male child was born in February 1958. In early infancy he had an operation of the left kidney, but otherwise he was well until the age of 31 years when he developed a skin rash and muscle contractures. Dermatomyositis was diagnosed, and the result of a muscle biopsy was as follows. 'The muscle shows areas of oedema, a patchy but diffuse inflammatory cell infiltrate composed of lymphocytes,...

Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disorder caused by polyglutamine expansion in the androgen receptor (AR) and characterized by the loss of lower motor neurons. Here we investigated pathological processes occurring in muscle biopsy specimens derived from SBMA patients and, as controls, age-matched healthy subjects and patients suffering from amyotrophic lateral sclero...

The fine structure of smooth muscle cells of the embryo chicken gizzard cultured in monolayer was studied by phase-contrast optics and electron microscopy. The smooth muscle cells were irregular in shape, but tended to be elongate. The nucleus usually contained prominent nucleoli and was large in relation to the cell body. When fixed with glutaraldehyde, three different types of filaments were ...

Dark-cutting beef is a condition in which fails to have characteristic bright-red color when the cut surface exposed oxygen. However, mechanistic basis for this occurrence not clear. Protein expression profiles were compared between dark-cutting and normal-pH using LC-MS/MS-based proteomics. Mass spectrometry analysis identified 1162 proteins proteomes of beef. Of these, 92 had significant chan...

The accessory flexor muscle of the crab myochordotonal organ consists of two kinds of muscle-fibres. In one type the fibrillar material has a uniform punctate appearance in cross-section. The Z bands are often broken across the fibre width and are spaced 2 to 3/n apart. These resemble the 'Fibrillenstruktur' muscle of vertebrates. In the second fibre type the fibrillar material appears as large...

Most of the matter in the universe is invisible. I review the status of dark matter and describe how both the theory of galaxy formation and novel types of experimental searches are revitalizing attempts to find non-baryonic dark matter.