AIMS Although frequent reduction or loss of DCC (deleted in colorectal carcinomas) has been demonstrated in gliomas, the association with cell kinetics and survival is still unclear. METHODS A total of 119 astrocytomas, comprising 39 grade IV, 36 grade III, and 44 low grade tumours, were immunohistochemically investigated, along with 26 normal adult brain samples and two fetal brains. The res...

We argue that disoriented chiral condensate (DCC) domains are not well defined for temperatures above the Ginzburg temperature TG (≃ 0.7Tc). Above TG, the dynamics of DCC domains is dominated by thermal fluctuations leading to fluctuating orientation of the chiral field in a given domain. It implies that DCC domains may form even in relatively lower energy collisions where the temperature only ...

In many organisms, it remains unclear how X chromosomes are specified for dosage compensation, since DNA sequence motifs shown to be important for dosage compensation complex (DCC) recruitment are themselves not X-specific. Here, we addressed this problem in C. elegans. We found that the DCC recruiter, SDC-2, is required to maintain open chromatin at a small number of primary DCC recruitment si...

BACKGROUND Biventricular direct cardiac compression (DCC) can potentially support the failing heart without the complications associated with a blood/device interface. The effect of uniform DCC on left and right ventricular performance was evaluated in 7 isolated canine heart preparations. METHODS AND RESULTS A computer-controlled afterload system either constrained the isolated heart to cont...

AIM OF THE STUDY To assess quality of life (QoL) in cancer patients treated at home, at an in-patient palliative care unit (PCU), and at a day care center (DCC). PATIENTS AND METHODS QoL was assessed in advanced cancer patients at baseline and after 7 days of symptomatic treatment using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 15-Pallia...

We consider the quantum state describing the Disoriented Chiral Condensate (DCC), which may be produced in high energy collisions. We show how a mean eld treatment of the quantum equations corresponding to the classical linear sigma model leads to a squeezed state description of the pions emerging from the DCC. We examine various squeezed and coherent state descriptions of those pions with part...

Alterations and defective expression of three putative tumor-suppressor genes, the deleted in colorectal cancer (DCC), p51, and O(6)-methylguanine-DNA methyltransferase (MGMT), have been demonstrated in many cancers. However, it is not known whether the defective expression of each of these genes is independent or whether it reflects a specific methylation abnormality. Here, we investigated the...

Maria Lúcia Bento Villela DCC – ICEx UFMG DECOM – FACET UFVJM Campus JK Rodovia MGT 367 Km 583, no 5000 CEP 39100-000 Diamantina Minas Gerais Brasil [email protected] Simone Xavier DCC – ICEx UFMG Av. Antônio Carlos 6627 CEP 31270-010 Belo Horizonte Minas Gerais Brasil [email protected] Raquel Oliveira Prates DCC – ICEx UFMG Av. Antônio Carlos 6627 CEP 31270-010 Belo Horizonte Minas ...

[reaction: see text] Dynamic combinatorial chemistry (DCC) is a promising technique for receptor-aided selection of high-affinity ligands from equilibrating combinatorial libraries. Identification of the specific ligand(s) selected is often challenging, however, due to difficulties associated with chromatographic separation and/or mass degeneracy within the library. Herein, we describe proof-of...

Loss of heterozygosity (LOH) on chromosome 18q21 is found frequently in various human cancers. Three candidate tumor suppressor genes, DCC (deleted in colorectal carcinomas), DPC4 (deleted in pancreatic carcinomas, locus 4), and MADR2/JV18-1 (MAD-related gene 2), have been cloned and identified from this chromosome region. We have reported recently that LOH on chromosome 18q is observed frequen...