A number of genetic variants have been linked to increased risk of breast cancer. Little is, however, known about the prognostic significance of hereditary factors. Here, we investigated the frequency and prognostic significance of two ERBB4 promoter region variants, -782G>T (rs62626348) and -815A>T (rs62626347), in a cohort of 1010 breast cancer patients. The frequency of nine previously descr...

Direct digital frequency synthesizers (DDSs) are of interest in modern digital communication systems and high-precision function generation. Wide frequency synthesis range, agile and continuous phase frequency switching, fine frequency resolution, and the ability to synthesize arbitrary waveforms as well as sinewaves are some of the important advantages of this family of frequency synthesizers....

BACKGROUND Although the prognosis of patients with small (≤1cm) tumors is generally favorable, emerging data suggests that biological behavior varies between intrinsic subtypes in such patients. Furthermore, it still remains unclear whether HER2-positive pT1a-bN0M0 patients could benefit from adjuvant trastuzumab. For further evaluation, we sought to conduct a meta-analysis so as to get a bette...

Direct sequence spread Spectrum (DSSS), is also called as direct sequence code division multiplexing (DS-CDMA). In direct sequence spread spectrum, the stream of information to be transmitted is divided into small pieces, each of which is allocated across to a frequency channel across the spectrum. A data signal at the point of transmission is combined with a higher data-rate bit sequence (also...

BACKGROUND & AIMS Breast cancer (BC) is prevalent worldwide malignant cancer. Improvements in timely and effective diagnosis and prediction are needed. As reported, secreted DAND5 is contributed to BC metastasis. We aim to assess whether DAND5 in peripheral blood serum could determine BC-specific mortality. METHODS We used immunohistochemistry staining to detect DAND5 expression in our BC tis...

The main difficulty all model checking tools encounter with is the state explosion problem: the state space of a system model grows exponentially with the number of processes of the system. Various techniques (abstraction, partial order reduction, symmetry reduction, etc.) have been developed to cope with this problem by taking advantages of specific algebraic features of particular models. Sym...

The use of anomalous X-ray scattering to obtain the first differences and partial structure factors normally obtained with isotopic substitution neutron diffraction is described and compared with the neutron technique. Both the problems associated with the X-ray technique and the situations in which it is highly valuable are discussed. The availability of tunable, intense synchrotron radiation ...

Abstract. Meltwater from mountainous catchments dominated by snow and ice is a valuable source of fresh water in many regions. At mid-latitudes, seasonal cover glaciers act like natural reservoir storing precipitation during winter releasing it spring summer. Snowmelt usually modelled either energy balance or temperature-index approaches. The approach process-based more sophisticated but requir...

We use adiabatic perturbation theory to calculate the timing jitter induced by fluctuations in solitons amplitude, frequency and position due to amplifiers noise when ultrashort solitons ( ~ ! ps) are propagated in dispersion-decreasing fibers. The result is applied to a high-speed soliton communication system with amplifiers spacing of 50-100 km. We show that the transition from a regime where...