Abstract The COVID-19 pandemic has continued to affect people’s lives worldwide, and SARS-CoV-2, the pathogen that causes pandemic, infected over 100 million people claimed 10 globally. There is strong evidence lung damage contributes inflammatory responses against diverse forms of cell death occur in myeloid cells upon infection. However, less known about pathways activated primary target epit...

Abstract Some specific chemotherapeutic drugs are able to enhance tumor immunogenicity and facilitate antitumor immunity by inducing immunogenic cell death (ICD). However, immunosuppression induced the adenosine pathway hampers this effect. In study, E-selectin-modified thermal-sensitive micelles designed co-deliver a drug (doxorubicin, DOX) an A2A receptor antagonist (SCH 58261), which simulta...

Apoptosis is a highly regulated cell death mechanism involved in many physiological processes. A key component of extrinsically activated apoptosis is the death receptor Fas which, on binding to its cognate ligand FasL, oligomerize to form the death-inducing signaling complex. Motivated by recent experimental data, we propose a mathematical model of death ligand-receptor dynamics where FasL act...

Resistance to death receptor-mediated apoptosis is supposed to be important for the deregulated growth of B cell lymphoma. Hodgkin/Reed-Sternberg (HRS) cells, the malignant cells of classical Hodgkin's lymphoma (cHL), resist CD95-induced apoptosis. Therefore, we analyzed death receptor signaling, in particular the CD95 pathway, in these cells. High level CD95 expression allowed a rapid formatio...

Adoptive transfer of specific cytotoxic T lymphocytes (CTL) and Cytokine Induced Killer Cells (CIK) following genetic engineering of T-cell receptor zeta hold promising perspective in immunotherapy. In the present work we focused on the mechanisms of anti-tumor action of effectors transduced with an anti-CD19 chimaeric receptor in the context of B-lineage acute lymphoblastic leukemia (B-ALL). P...

Morin (2',3,4',5,7‑pentahydroxyflavone), a flavonoid isolated from members of the Moraceae family and leaves Cudranaia tricuspidata Buread, is well‑known natural substance with anti‑inflammatory, antioxidative, antimetastasis, anticancer effects. However, its activity has not been comprehensively investigated in human epidermal growth factor receptor 2 (HER2)‑overexpressing breast canc...

Necroptosis is a form of cell death that can be observed downstream of death receptor or pattern recognition receptor signaling under certain cellular contexts, or in response to some viral and bacterial infections. The receptor interacting protein kinases-1 (RIPK1) and RIPK3 are at the core of necroptotic signaling, among other proteins. Because this pathway is normally halted by the pro-apopt...

Fibroblast growth factor (FGF)-inducible 14 (Fn14) activates the classical and alternative NFκB (nuclear ‘kappa-light-chain-enhancer’ of activated B-cells) signaling pathway but also enhances tumor necrosis (TNF)-induced cell death. Fn14 expression is upregulated in non-hematopoietic cells during tissue injury often highly expressed solid cancers. In view latter, there were are considerable pre...

cFLIP (cellular FLICE-like inhibitory protein) is structurally related to caspase-8 but lacks proteolytic activity due to multiple amino acid substitutions of catalytically important residues. cFLIP protein is evolutionarily conserved and expressed as three functionally different isoforms in humans (cFLIPL, cFLIPS, and cFLIPR). cFLIP controls not only the classical death receptor-mediated extri...