Paresthesiae-producing deep brain stimulation (stimulation of ventrocaudal nucleus-VC, medial lemniscus-ML or internal capsule-IC) is one of the few procedures to treat the steady element of neural injury pain (NIP) currently available. Reviewing the first 60 patients with NIP submitted to deep brain stimulation (DBS) from 1978 to 1991 at the Division of Neurosurgery, Toronto Hospital, Universi...

The year 2017 marks the 30th anniversary of the birth of modern deep brain stimulation (DBS), which was introduced by Benabid, Pollak et al. in 1987, initially targeting the motor thalamus to treat tremor, and subsequently targeting the subthalamic nucleus (STN) for treatment of symptoms of advanced Parkinson's disease (PD). STN DBS is undoubtedly "the most important discovery since levodopa", ...

OBJECTIVE Brain-computer interfaces (BCIs) could potentially be used to interact with pathological brain signals to intervene and ameliorate their effects in disease states. Here, we provide proof-of-principle of this approach by using a BCI to interpret pathological brain activity in patients with advanced Parkinson disease (PD) and to use this feedback to control when therapeutic deep brain s...

Deep brain stimulation (DBS) is an established therapy for the treatment of movement disorders, and has shown promising results for the treatment of a wide range of other neurological disorders. However, little is known about the mechanism of action of DBS or the volume of brain tissue affected by stimulation. We have developed methods that use anatomical and diffusion tensor MRI (DTI) data to ...

BACKGROUND Deep brain stimulation has been widely used for treating several movement disorders including idiopathic Parkinson disease (IPD). The development of hemiballism after an iatrogenic injury to the subthalamic nucleus (STN) such as postoperative hemorrhage or stroke is rare. Employing pallidal DBS to manage hemiballism arising as a result of STN injury is a unique application of this th...

Abstract Deep brain stimulation (DBS) of circuits involved in mood regulation is a novel tool that being investigated as potential treatment for some the most severe patients with disorders. At UTHealth Houston, we have had an ongoing clinical trial DBS medial forebrain bundle (MFB). Our preliminary results suggest effects alleviating depressive symptoms this very severe, refractory patient gro...

BackgroundHigh frequency (130 Hz) subthalamic Deep-Brain-Stimulation (STN-DBS) optimally improves cardinal motor symptoms in Parkinson disease (PD). Low stimulation frequencies (60–80 improve axial some patients and, according to preliminary evidences, may also have a beneficial effect on the cognitive component of planning.ObjectiveTo analyze configuration P300 cortical event-related auditory ...

Deep brain stimulation (DBS) is an established therapeutic modality for the treatment of movement disorders and an emerging therapeutic approach for the treatment of disorders of mood and thought. For example, recently we have shown that DBS of the fornix may ameliorate cognitive decline associated with dementia. However, like other applications of DBS, the mechanisms mediating these clinical e...

introduction: parkinson’s disease is one of the most disabling diseases which by electrode implantation and stimulation of subthalamic nucleus (stn), much progress has been made in the treatment of drug resistant patient. this new method of neurosurgery may have some neuropsychological side effects on the patients. the main aim of this study is to evaluate the effects of this kind of treatment ...

BACKGROUND Anterior nucleus (AN) deep brain stimulation (DBS) is a palliative treatment for medically refractory epilepsy. The long-term efficacy and the optimal target localization for AN DBS are not well understood. OBJECTIVE To analyze the long-term efficacy of AN DBS and its predictors. METHODS We performed a retrospective review of 16 patients who underwent AN DBS. We selected only pat...