Investigations of the cerebellar nuclei and the white matter adjacent to them have been very few in number as compared with many studies of cerebellar function based upon gross extirpation of this organ or upon destruction or stimulation of its cortex. It is well known, however, that the nuclei constitute at least the major source of all efferent cerebellar connections, and the small amount of ...

In a previous study, we found that neurons in the deep cerebellar nuclei (DCN) respond to 5-ms brief facial tactile stimulation in rats anesthetized with ketamine-xylazine with multiphasic response patterns lasting over 200 ms. It remained unclear, however, to what extent these responses were shaped not only by ascending sensory input from the trigeminal nuclei but also by interactions with oth...

The deep cerebellar nuclei (DCN) are the main output centers of the cerebellum, but little is known about their development. Using transcription factors as cell type-specific markers, we found that DCN neurons in mice are produced in the rhombic lip and migrate rostrally in a subpial stream to the nuclear transitory zone (NTZ). The rhombic lip-derived cells express transcription factors Pax6, T...

compound-nucleus reactions provide the standard mechanism to populate states with high angularmomentum in neutron deficient nuclei. neutron-rich nuclei with mass aand induced fission. projectile fragmentation has proven to be an efficient method of populating nuclei farfrom the valley of stability. however, in the case of heavy nuclei this method is still limited to species withisomeric states....

PURPOSE To describe MR changes in the cerebellar cortex and the dentate nucleus in patients with inferior olivary nucleus hypertrophy. METHODS MR scans of 11 patients with palatal myoclonus were reviewed. Among them, we selected 5 cases that showed lesions in the central tegmental tract and the ipsilateral inferior olivary nucleus. We evaluated MR changes of the cerebellar cortices and dentat...

Citation: Watson TC (2015) " And the little brain said to the big brain… " Editorial: Distributed networks: new outlooks on cerebellar function Front. The purpose of this research topic is to showcase recent anatomical, physiological, and clinical studies revealing how the cerebellum is embedded within distributed neural networks recruited during both direct motor functions plus cognitive and o...

The output of the cerebellar cortex is controlled by two main inputs, (i.e., the climbing fiber and mossy fiber-parallel fiber pathway) and activations of these inputs elicit characteristic effects in its Purkinje cells: that is, the so-called complex spikes and simple spikes. Target neurons of the Purkinje cells in the cerebellar nuclei show rebound firing, which has been implicated in the pro...

Knowledge of body motion through space is necessary for spatial orientation, self-motion perception, and postural control. Yet, sensory afferent signals may not directly provide such information to the brain. Because motion detected by the vestibular end organs is encoded in a head-fixed frame of reference, a coordinate transformation is thus required to encode body motion. In this study, we in...

Background: Harmaline and harmine are tremorigenic b-carbolines that, on administration to experimental animals, induce an acute postural and kinetic tremor of axial and truncal musculature. This drug-induced action tremor has been proposed as a model of essential tremor. Here we review what is known about harmaline tremor. Methods: Using the terms harmaline and harmine on PubMed, we searched f...

BACKGROUND Harmaline and harmine are tremorigenic β-carbolines that, on administration to experimental animals, induce an acute postural and kinetic tremor of axial and truncal musculature. This drug-induced action tremor has been proposed as a model of essential tremor. Here we review what is known about harmaline tremor. METHODS Using the terms harmaline and harmine on PubMed, we searched f...