In a randomized prospective trial of prophylactic antibiotics in at-risk abdominal surgery, one dose of intravenous Augmentin (amoxycillin 250 mg and clavulanic acid 125 mg) on induction has been compared with three 8 hourly doses in 900 patients. Wound infection rates which included minor and delayed infections were very similar in those given one dose: 48/449 (10.7%) compared with those given...

BACKGROUND Sepsis is usually accompanied by changes of body temperature (Tb), but whether fever and hypothermia predict mortality equally or differently is not fully clarified. We aimed to find an association between Tb and mortality in septic patients with meta-analysis of clinical trials. METHODS We searched the PubMed, EMBASE, and Cochrane Controlled Trials Registry databases (from incepti...

materials and methods the level of plasma il-6 and blood culture were checked in all the term neonates suspicious to sepsis admitted to the neonatal intensive care unit of shahid beheshti hospital of kashan during 2010-2011. positive blood culture was considered as definite sepsis and negative blood culture as suspicious sepsis. then, the level of il-6 was compared with the state of blood cultu...

background one of the main components involving in the pathogenesis and prognosis of sepsis and septic shock is natriuretic peptide. hemodynamic changes in sepsis or septic shock might explain increased plasma levels of these peptides circulations. objectives the present study aimed to assess the value of brain natriuretic peptide (bnp) in prediction of sepsis state and its related morbidity. w...

OBJECTIVES Sepsis affects nearly 1 million people in the United States per year, has a mortality rate of 28-50% and requires more than $20 billion a year in hospital costs. Over a quarter century of research has not yielded a single reliable diagnostic test or a directed therapeutic agent for sepsis. Central to this insufficiency is the fact that sepsis remains a clinical/physiological diagnosi...

OBJECTIVE To evaluate the performance of EuroSCORE in the prediction of in-hospital postoperative length of stay and specific major postoperative complications after cardiac surgery. METHODS Data on 5051 consecutive patients (isolated [74.4%] or combined coronary artery bypass grafting [11.1%], valve surgery [12.0%] and thoracic aortic surgery [2.5%]) were prospectively collected. The EuroSCO...

case presentation we describe a case of a previously healthy child who presented with sepsis due to varicella gangrenosa. while she initially responded well to a conservative antibiotic and acyclovir treatment, her subsequent rapid deterioration required urgent and repeated debridement. conclusions this report highlights the significance of prompt diagnosis and early surgical intervention for m...

background: in the recent decades, the prevalence of nosocomial infections in neonates has grown and almost 21% of preterm neonates experience these kinds of infections. some factors were proposed to have a protective effect against neonatal infections through promoting the development of the immune system of the newborn. this study aimed to evaluate the efficacy of oral glutamine supplementati...