Corticosteroids (CS) are the most frequently used class of highly potent anti-inflammatory and immunosuppressant agents in clinical practice for various clinical indications (1). However, their long-term use is associated with serious side effects, which restrict their clinical utility (2-3). Even low dose CS treatment has been suggested to be not free from risks (4). Moreover, cutaneous advers...

Figure 1 (A) Chest radiography: heterogeneous infiltration in the right upper lobe and homogeneous opacity in the left hilar region. (B)--(D) Chest Computed Tomography of the thorax: hypodense mass of 9 cm with well defined margins located in the mediastinum with extension to the left upper lobe, areas of consolidation in the right upper lobe associated with micro-nodular infiltration and groun...

The most appropiate management for bronchial asthma is the control of airway inflammation. Corticosteroids are the most effective anti-inflammatory drugs available, but they have a number of side effects; most of these are dose-dependent. In children, asthma control should be accomplished with low steroid doses possibly given by inhalation. In a double-bind placebo-controlled crossover study a ...

Tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare disease, often underdiagnosed or misdiagnosed in children. We describe the case of a 12-year-old boy who presented to Severance Hospital with a 1-month history of bilateral conjunctival injection. He was first evaluated by an Ophthalmologist in another hospital and diagnosed with panuveitis. Laboratory tests indicated renal fail...

Topical corticosteroids are frequently recognised as a cause of allergic contact dermatitis but in only few cases the administration of intranasal corticosteroids has been reported as the cause of systemic allergic reaction.1--6 A 34-year-old non-atopic woman started treatment with nasal budesonide for a common cold. On the second day of treatment the patient developed, 8 h after the administra...

To compare the effects of deflazacort (DEFLA) vs. prednisone (PRED) on bone mineral density (BMD), body composition, and lipids, 24 patients with end-stage renal disease were randomized in a double blind design and followed 78 weeks after kidney transplantation. BMD and body composition were assessed using dual energy x-ray absorptiometry. Seventeen patients completed the study. Glucocorticoste...

This is a male 23-year-old patient presenting with right tinnitus, ipsilateral hypoacusis and dizziness following three months of diarrhea and weight loss. The patient was taking deflazacort and budesonide, which improved his intestinal, hearing and postural symptoms, but not the tinnitus. Initial audiometry revealed mild right sensorineural dysacusis. Laboratory exams included a positive ANF, ...

A 52 year old gentleman; jeweller by profession, residing in rural Goa, was admitted to our institution in March 2013 with complaints of chest pain, fever and dry cough for 2 weeks prior to admission. He was admitted to a hospital in Goa for two days prior to the present admission where he was found to have a raised WBC count of 18000/cm3 with a neutrophilic predominance. Chest x-ray showed a r...

To cite: Behera V, Behera MK, Chauhan R, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2014205296 DESCRIPTION A 15-year-old boy presented with progressive proximal weakness of the lower limbs starting at 4 years of age followed by involvement of the upper limbs. He is the product of a consanguineous marriage; he had a family history of similar disease in ...