Over 600,000 bone-grafting operations are performed each year in the United States. The majority of the bone used for these surgeries comes from autografts that are limited in quantity or allografts with high failure rates. Current synthetic bone grafting materials have poor mechanical properties, handling characteristics, and bioactivity. The goal of this dissertation was to develop a clinical...

A reactive oxygen species (ROS)-degradable scaffold is fabricated by crosslinking biocompatible, hydrolytically-degradable poly(ε-caprolactone) (PCL) with a ROS-degradable oligoproline peptide, KP7K. The ROS-mediated degradability triggers favorable host responses of the scaffold including improved cell infiltration and angiogenesis in vivo, indicating its unique advantages for tissue engineeri...

The development of metal alloys with porosity controlled by powder metallurgy has shown to be suitable for obtaining biomaterials the control mechanical strength and modulus elasticity, in addition possibility controlling open porosity, which is essential osseointegration. Magnesium have encouraging results when used as tissue engineering scaffolds. Although a considerable number studies encour...

Extended life expectancy and medical development has led to an increased reliance on biomaterial implants and devices to support or restore human anatomy and function. However, the presence of an implanted biomaterial results in an increased susceptibility to infection. Due to the severity of the potential outcomes of biomaterial-associated infection, different strategies have been employed to ...

objective: biomaterial technology, when combined with emerging human induced pluripotent stem cell (hipsc) technology, provides a promising strategy for patient-specific tissue engineering. in this study, we have evaluated the physical effects of collagen scaffolds fabricated at various freezing temperatures on the behavior of hipsc-derived neural progenitors (hipsc-nps). in addition, the coati...

Immobilization using external or internal splints is a standard and effective procedure to treat minor skeletal fractures. In the case of major defects caused by extreme trauma, infectious diseases tumors, surgical implantation bone graft from sources required for complete cure. Practical disadvantages, such as risk immune rejection infection at implant site, are high in xenografts allografts. ...

Degradable hydrogels to deliver bioactive proteins represent an emerging platform for promoting tissue repair and vascularization in various applications. However, implanting these biomaterials requires invasive surgery, which is associated with complications such as inflammation, scarring, and infection. To address these shortcomings, we applied microfluidics-based polymerization to engineer i...

Becker et al., "Three-Dimensional Growth and Differentiation of Ovarian Tumor Cell Line in High Aspect Rotating-Wall Vessel: Morphologic and Embryologic Considerations", J. Cellular Biochem. 1993 51(3):283-289. Burwell R.G. Bone Grafts, Derivatives and Substitutes., M.R. Urist and R.G. Burwell, Editors 1994, Butterworth-Heinemann Ltd.: Oxford. Casser-Bette et al., "Bone Formation by Osteoblast-...

nanofibrous scaffolds produced by electrospinning have attracted much attention, recently. aligned and random nanofibrous scaffolds of poly (vinyl alcohol) (pva), poly (ε-caprolactone) (pcl) and nanohydroxyapatite  (nha) were fabricated by electrospinning method in this study. the composite nanofibrous scaffolds were subjected to detailed analysis. morphological investigations revealed that the...