Deficits in GABAergic inhibitory neurotransmission are a reliable finding in schizophrenia (SCZ) patients. Previous studies have reported that unaffected first-degree relatives of patients with SCZ demonstrate neurophysiological abnormalities that are intermediate between probands and healthy controls. In this study, first-degree relatives of patients with SCZ and their related probands were in...

Skin tests and exercise tests were performed on children with cystic fibrosis (CF) and first-degree relatives of CF children. Positive skin tests were found in 56% of patients and 19% of relatives, but the prevalence of atopy in CF patients bore no relationship to its prevalence in their relatives. Increased 0ronchial lability, mainly due to bronchoconstriction, was present in 54% of patients a...

S everal studies have suggested that vascular changes precede the development of metabolic disorders in first-degree relatives of subjects with type 2 diabetes, indicating that being a first-degree relative of a subject with type 2 diabetes is a risk per se for vascular dysfunction (1–3). However, these studies have failed to control for relevant metabolic and inflammatory variables that are us...

BACKGROUND Previous studies have shown increased familial risk for chronic lymphocytic leukemia. In the most comprehensive study to date, we evaluated risk of chronic lymphocytic leukemia and lymphoproliferative disorders among first-degree relatives of chronic lymphocytic leukemia cases compared to first-degree relatives of controls. DESIGN AND METHODS Population-based registry data from Swe...

PURPOSE To report the results of screening first degree relatives of persons identified with primary open angle glaucoma in a tertiary eye hospital glaucoma services. DESIGN A cross-sectional study of first degree relatives of persons with primary open angle glaucoma. MATERIALS AND METHODS First degree relatives of patients identified with primary open angle glaucoma were invited to partici...

Splenic function was assessed using 'pitted' erythrocyte counts in 61 first degree relatives of patients with coeliac disease. 'Pitted' erythrocyte counts were normal in 12 parents, but were raised in 20% of 49 siblings and/or children of coeliac patients. First degree relatives had higher 'pitted' erythrocyte counts than normal controls (p = 0.002). The counts were lower in coeliac relatives t...

OBJECTIVE To use a statewide population-based genealogic database to evaluate the relationship between Parkinson disease (PD) and cancer subtypes. DESIGN Using a computerized genealogy for the Utah pioneers and their descendants linked to a statewide cancer registry and statewide death certificates, we estimated relative risks for cancer in individuals with PD listed on their death certificate,...

Background: In sub-Saharan Africa (SSA), the trend in the number of patients admitted for maintenance hemodialysis is on the rise. The identification of risk factors for chronic kidney disease (CKD) ensures adequate primary and secondary preventive measures geared at reducing the burden of CKD in low-resource settings. A family history of CKD is an established risk factor for C...

Objective: Adiponectin (an insulin sensitizing protein) and zinc have insulin like effect. This study was conducted to assess the effect of zinc supplementation on serum adiponectin and insulin resistance in first degree relatives of diabetic patients. Materials and Methods: This study was a randomized clinical trial performed on 58 first degree relatives of diabetic patients with normal gluco...

OBJECTIVE AND METHODS To assess the validity of the family history obtained at the bedside of patients with recent subarachnoid haemorrhage by subsequently contacting all first and second degree relatives, with verification from medical record data. RESULTS In a prospectively collected series of 163 patients with recent subarachnoid haemorrhage the history or cause of death could be ascertain...