Background: Hypothyroidism is a decrease in the production of thyroid hormones and leads to gland dysfunction. Ashwagandha extract was used as an ayurvedic treatment supposed be antihypothyroidism agent. Objectives: investigate impact ashwagandha (Ash) on propylthiouracil (PTU)-induced hypothyroidism rats. Subjects Methods: The rats were divided into three groups, control group, PTU (hypothyroi...

Pattern separation is a fundamental brain computation that converts small differences in input patterns into large output patterns. Several synaptic mechanisms of pattern have been proposed, including code expansion, inhibition and plasticity; however, which these play role the entorhinal cortex (EC)–dentate gyrus (DG)–CA3 circuit, classical remains unclear. Here we show biologically realistic,...

The dentate gyrus is the chief route of excitatory input into the hippocampal formation and is thus crucial for appropriate function of the hippocampus in learning and memory. Many pathological states associated with histological abnormalities in the dentate are likely to have their origins during development. These disorders include generalized abnormalities of neuronal migration, e.g. reeler ...

Since the discovery of nerve growth factor (NGF) in the 1950s and brain-derived neurotrophic factor (BDNF) in the 1980s, a great deal of evidence has mounted for the roles of neurotrophins (NGF; BDNF; neurotrophin-3, NT-3; and neurotrophin-4/5, NT-4/5) in development, physiology, and pathology. BDNF in particular has important roles in neural development and cell survival, as well as appearing ...

Electromagnetic fields (EMFs) inhibit the formation and differentiation of neural stem cells during embryonic development. In this study, the effects of prenatal exposure to EMF on the number of granule cells in the dentate gyrus of 4-week-old rats were investigated. This experiment used a control (Cont) group and an EMF exposed (EMF) group (three pregnant rats each group). The EMF group consis...

The role of dentate gyrus in hippocampal mnemonic processing is uncertain. One proposed role of dentate gyrus is binding internally generated spatial representation with sensory information on external landmarks. To test this hypothesis, we compared effects of visual input on spatial firing of CA1 neurons in Bax knock-out mice in which dentate gyrus neural circuitry is selectively disrupted. Wh...

With continued debate over the functional significance of adult neurogenesis, identifying an in vivo correlate of neurogenesis has become an important goal. Here we rely on the coupling between neurogenesis and angiogenesis and test whether MRI measurements of cerebral blood volume (CBV) provide an imaging correlate of neurogenesis. First, we used an MRI approach to generate CBV maps over time ...

The dentate gyrus of the rat produces new granule neurons well into adulthood. In the adult, newly born granule neurons migrate from the hilus to the granule cell layer, receive synaptic input, extend axons into the mossy fiber pathway, and express a neuronal marker. No previous studies have identified factors that regulate neuronal birth in the adult dentate gyrus. In order to determine whethe...

BACKGROUND AND PURPOSE Spreading depression (SD) is an epiphenomenon of neurological disorders, like stroke or traumatic brain injury. These diseases have been associated with an increased neurogenesis in the adult rodent dentate gyrus. Such proliferative activity can also be induced by conditions that--like SD--coincide with a disturbed neuronal excitability, eg, epilepsy. Thus we hypothesized...