the traveling salesman problem (tsp) is the problem of finding the shortest tour through all the nodes that a salesman has to visit. the tsp is probably the most famous and extensively studied problem in the field of combinatorial optimization. because this problem is an np-hard problem, practical large-scale instances cannot be solved by exact algorithms within acceptable computational times. ...

Voltage-gated Na+ channels are major targets of G protein-coupled receptor (GPCR)-initiated signaling cascades. These cascades act principally through protein kinase-mediated phosphorylation of the channel alpha subunit. Phosphorylation reduces Na+ channel availability in most instances without producing major alterations of fast channel gating. The nature of this change in availability is poor...

In this article, we study the asymptotic behaviour of least-square estimator in a linear regression model based on random observation instances. We provide mild assumptions moments and dependence structure randomly spaced observations residuals under which is strongly consistent. particular, consider instances that are negatively superadditive dependent within each other, while for merely assum...

nayshābūr achieved considerable scholarly growth in the 3rd-6th/9th-12th centuries that was coupled with some ups and downs. this scholarly and academic growth was associated with desirable economic conditions. one of the instances of desirable economic conditions in nayshābūr was manifested in the scholars’ livelihood, and therefore, the scholars’ academic progress was to some extent dependent...

In a recent work, Beierle, Brinkmann and Leander presented recursive tree search for finding APN permutations with linear self-equivalences in small dimensions. this paper, we describe how can be adapted to find many new instances of quadratic functions. particular, found 12,921 functions dimension eight, 35 nine five ten up CCZ-equivalence. Remarkably, two the are permutations. Among 8-bit fun...

The process regarding the formation of different mosque gardens and the elements that contribute to the respective process is the from the foci point of this paper. The significance of the topic lies in the fact that certain scholars have associated the courtyard in mosques with the concept of garden, and have not taken into account the elements that contribute to the development of various typ...