Background: We examine the GA-repeat core promoters of MECOM and GABRA3 in human embryonic kidney-293 cell line and show that those GA-repeats have promoter activity,and those different alleles of the repeats can significantly alter gene expression.We propose a novel role for GA-repeat core promoters to regulate gene expression in the genes involved in development and evolution. Materials and M...

From development to disease When brain goes awry, whether in genes or cells circuits, neurodevelopmental disorders ensue. Klingler et al. review how disrupted leads clinical symptoms, with a particular focus on the linkage between cortical malformations and neuropsychiatric disorders. The complexity of developmental process may underlie variability symptoms. Science , this issue p. eaba4517

Plants produce two phosphorylated enzymes: pyrophosphate-dependent fructose-6-phosphate phosphotransferase (PFP) and ATP-dependent phosphofructokinase (PFK). However, the characterization of (PFK) family members their functions remains unexplored in Eastern Cottonwood (Populus deltoides). This study comprehensively analyzed 17 genes P. deltoides genome, including gene structure, conserved domai...

A major focus of evolutionary developmental (evo-devo) studies is to determine the genetic basis of variation in organismal form and function, both of which are fundamental to biological diversification. Pioneering work on metazoan and flowering plant systems has revealed conserved sets of genes that underlie the bauplan of organisms derived from a common ancestor. However, the extent to which ...