Functional diversity in the distinct developmental stages as well as anti-pathogen effectiveness and memory functionality make B cells unique and attractive object of physiology studies of the immune system. B cells are produced throughout the life of an organism, originate from the hematopoietic stem cells before birth and continue to differentiate to terminal stages. Over the past decade, the...

Jennifer Nichols is a Principal Investigator at the Cambridge Stem Cell Institute and Department of Physiology, Development and Neuroscience at the University of Cambridge, UK. Her lab works on lineage segregation and the establishment of pluripotency in the mammalian embryo. In 2017 she was awarded the British Society for Developmental Biology's Cheryll Tickle Medal, given to mid-career female...

State Key Laboratory of Crop Biology, Shandong Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University, Taian, Shandong 271018, China. Current address: Key Laboratory of Photosynthesis and Environmental Molecular Physiology, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China. Section of Cell and Developmental Biology, University of Califor...

Venous varix occurring with a developmental venous anomaly is a rare disease entity that may be found incidentally by conventional cerebral angiography. Developmental venous anomaly (DVA) without venous varix has a normal physiology, and thus, in most cases treatment is not necessary. Although most varices with venous anomalies are known to be clinically silent but if hemorrhage from increased ...

2003;553;695-706; originally published online Oct 3, 2003; J. Physiol. Patrick J. Whelan mouse spinal cord preparation in vitro Developmental aspects of spinal locomotor function: insights from using the This information is current as of July 24, 2007 publication unless article is open access. This version of the article may not be posted on a public website for 12 months after http://jp.physoc...

Hormonal control of post-embryonic morphogenesis is well established, but it is not clear how differences in developmental endocrinology between species may underlie animal diversity. We studied this issue by comparing metamorphic thyroid hormone (TH) physiology and gonad development across spadefoot toad species divergent in metamorphic rate. Tissue TH content, in vitro tail tip sensitivity to...

Homeostasis is conventionally thought of merely as a synchronic (same time) servo-mechanism that maintains the status quo for organismal physiology. However, when seen from the perspective of developmental physiology, homeostasis is a robust, dynamic, intergenerational, diachronic (across-time) mechanism for the maintenance, perpetuation and modification of physiologic structure and function. T...

BACKGROUND Many changes in social behavior take place during adolescence. Sexuality and romantic interests emerge during this time, and adolescents spend more time with peers and less time with parents and family. While such changes in social behavior have been well documented in the literature, relatively few neurophysiological explanations for these behavioral changes have been presented. M...