BACKGROUND Plantar ulcers produced by diabetic foot disease are devastating and costly. Better understanding of the ulcer-producing process is important to improve detection of feet that are at risk and to improve intervention. We identified and quantified soft-tissue and osseous structural changes in the forefoot of diabetic patients with a prior plantar ulcer. METHODS Thirty-two individuals...

Telomerase is the enzyme that maintains telomere length by adding telomeric repeats after each cell division. Numerous metabolic factors such as obesity, insulin resistance or physical inactivity have been associated with shortened telomeres. In the present study, we assessed telomerase activity in diabetic patients having or not foot ulcer. A total of 90 adult patients with type 2 diabetes mel...

Introduction: Foot complications are a major cause of hospitalization in patients with Diabetes Mellitus (DM), which consumes high number hospital days because multiple surgical procedures and prolonged length stay. Patients DM have up to 25% lifetime risk developing foot ulcer, precedes amputation 85% cases. A mainstay Diabetic Ulcer (DFU) therapy is debridement all necrotic, callus, fibrous t...

Complications of diabetes that affect the lower extremities are common, complex, and costly. Foot ulceration is the most frequently recognized complication. In a community-based study in the northwestern United Kingdom, the prevalence of active foot ulcers identified at screening among persons with diabetes was 1.7%, and the annual incidence was 2.2%.1 Higher annual incidence rates have been re...

OBJECTIVE Foot ulceration is a serious complication of diabetes, and new techniques that can predict wound healing may prove very helpful. We tested the ability of medical hyperspectral technology (HT), a novel diagnostic scanning technique that can quantify tissue oxy- and deoxyhemoglobin to predict diabetic foot ulcer healing. RESEARCH DESIGN AND METHODS Ten type 1 diabetic patients with 21...

Objectives: The objectives of the study are to epidemiology and clinicopathogenesis diabetic foot ulcers (2) investigations that correlate with recurrence its management. Methods: This was done among patients came surgery outpatient department complaints ulcer, swelling, gangrene, over foot, toes/leg+foot/ankle admitted in ward C.R. Gardi Hospital, Ujjain, Madhya Pradesh, time period between Oc...

Background The aim of this paper was to create an updated Australian guideline on footwear for people with diabetes. Methods We reviewed new footwear publications, (inter)national guidelines, and consensus expert opinion alongside the 2013 Australian footwear guideline to formulate updated recommendations. Result We recommend health professionals managing people with diabetes should: (1) Ad...

BACKGROUND The aim of study was detailed analysis of the presentation of diabetic foot ulcers, characteristics and predictors of outcome (incidence of amputation in neuropathic, ischemic, neuro ischemic) in patients presenting with diabetic foot at our hospital. METHODS This prospective analytic study was conducted from January 2009-August 2010 at POF Hospital Wah Cantt. Diabetic patients who...

abstractintroduction: diabetes mellitus is the most common human metabolic disease and chronic non healing diabetic foot ulcers are a critical complication for these patients. angipars is a new herbal extract which has been introduced to accelerate healing of these ulcers. the purpose of this study was to investigate the efficacy and safety of oral angipars in patients with chronic diabetic foo...

The global prevalence of diabetes is predicted to double by the year 2030 from 2.8% to 4.4% (1). Of individuals with diabetes, a substantial number will develop lower extremity disease including peripheral neuropathy, foot ulcers, and peripheral arterial disease (PAD). In this chapter, the current epidemiology of lower extremity disease in individuals with diabetes is reviewed with a focus on f...