نتایج جستجو برای: diabetic cardiomyopathy

تعداد نتایج: 147964  

Journal: :International Journal of Research in Medical Sciences 2015

Journal: :Canadian journal of physiology and pharmacology 2005
Jiping Tang Sharyn M Fitzgerald Brandi N Boughtman Samuel W Cole Michael W Brands John H Zhang

Diabetic cardiomyopathy is 1 of the major causes of death in diabetic patients, but the pathogenesis is unclear. There is evidence that RhoA, a small GTPase, might be involved in cardiac function. This study, therefore, analyzed RhoA expression and activation in hearts of diabetic rats. Male Sprague-Dawley rats were divided into control and diabetic groups of 18 each. Diabetes was induced by in...

Journal: :Antioxidants & Redox Signaling 2015

Journal: :Academic Forensic Pathology 2016

Journal: :Circulation 2006
Jianxun Wang Ye Song Laila Elsherif Zhenyuan Song Guihua Zhou Sumanth D Prabhu Jack T Saari Lu Cai

BACKGROUND Our previous studies showed that transgenic mice that overexpress cardiac-specific metallothionein (MT) are highly resistant to diabetes-induced cardiomyopathy. Zinc is the major metal that binds to MT under physiological conditions and is a potent inducer of MT. The present study therefore explored whether zinc supplementation can protect against diabetic cardiomyopathy through card...

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