This study combines non-invasive hyperspectral imaging with an experimentally validated skin optical model and inverse algorithm to monitor diabetic feet of two representative patients. It aims to observe temporal changes in local epidermal thickness and oxyhemoglobin concentration and to gain insight into the progression of foot ulcer formation and healing. Foot ulceration is a debilitating co...

BACKGROUND Kiwifruit (Actindia Deliciosa) is demonstrated to have antibacterial and pro-angiogenic effects. It also contains proteolytic enzymes (actinidin) and ascorbic acid. In this study, the effects of Kiwifruit on neuropathic diabetic foot ulcer healing in clinical settings were evaluated. MATERIALS AND METHODS In this randomized clinical trial of 37 patients (17 in experimental and 20 i...

OBJECTIVE Tissue oxygen supply is crucial for wound healing. Especially in diabetic foot lesions, the chances for healing are mainly dependent on the presence or absence of ischemia. This study investigates the impact of the tissue O2 analysis system "O2C" for noninvasive quantification of tissue oxygenation in diabetic foot ulcer patients. RESEARCH DESIGN AND METHODS O2C assessed relative bl...

Abstract There are several factors that affect the efficiency of phagocytic activity in diabetic patients. In this study, a significant difference phagocytosis showed patients and controls (non-diabetic). The means were 43.05%, 52.70% 71.35% for foot ulcer, diabetes mellitus respectively. Age groups, mean blood glucose levels controlling fasting effects on (P-value = 0.022, 0.013 0.045) was rev...

OBJECTIVE The aim was to evaluate over 18 months whether depression was associated with mortality in people with their first foot ulcer. RESEARCH DESIGN AND METHODS A prospective cohort design was used. Adults with their first diabetic foot ulcer were recruited from foot clinics in southeast London, U.K. At baseline, the Schedules for Clinical Assessment in Neuropsychiatry 2.1 was used to def...

Some diabetic patients develop a diabetic peripheral neuropathy characterised by loss of sensation in the feet. Such patients have a high risk of injuries which often go unnoticed. Diabetic patients particularly those with neuropathy have abnormal pressure points under the feet. In these area, the skin gets thickened (called callus) which then becomes an ulcer. Chronic infection in the ulcer ul...

Background Diabetic foot ulcers are frequently related to elevated pressure under a bony prominence. Conservative treatment includes offloading with orthopaedic shoes and custom made orthotics or plaster casts. While casting in plaster is usually effective in achieving primary closure of foot ulcers, recurrence rates are high. Minimally invasive surgical offloading that includes correction of f...

M a i n r e s u l t s 5 trials met the selection criteria. 3 trials compared hydrogel as a method of debridement with standard wound care (good wound care or gauze). 1 trial compared hydrogel with larval therapy. 1 trial compared surgical debridement with conservative care. In all 5 trials, the primary outcome was complete wound closure. Sample sizes ranged from 29 to 172 patients. In 4 trials,...

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