A new ruthenium complex catalyzes the amination of primary and secondary alcohols and the regioselective mono- and sequential diamination of diols via the borrowing hydrogen pathway. Several variations on new intra- and intermolecular cyclizations of aminoalcohols, diols and diamines lead to heterocyclic ring systems.

A series of diamines and amino alcohols derived from 1-dodecanol, 1-tetradecanol, 1,2-dodecanediol and 1,2-tetradecanediol were synthesized and tested for their antitubercular activity. Compounds 3, 8 and 9 were found to be the most active (MIC of 6.25 microg/mL). Nine other compounds displayed activity against Mycobacterium tuberculosis, with a MIC of 12.5 microg/mL.

Ornithine decarboxylase (ODC) activity of Ehrlich carcinoma cells was increased more than 36-fold after being maintained for 3.5 hr in vitro in a special chamber which allowed continuous perifusion with 0.5 mM ornithine; if incubated in vitro without perifusion the ODC activity was, of course, only 9-fold by the same concentration of ornithine. Ornithine withdrawal from the perifusion medium re...

O-Functionalised salen ligands were employed as bridging ligands in the synthesis of homo- and heterometallic salen complexes with early and late transition metals (H(2)salen: N,N'-bis(salicylidene)ethylenediamine, systematic name: 2,2'-{ethane-1,2-diylbis(nitrilomethylidine)}diphenol). A new type of O-functionalised salen ligand was synthesised, which contains alkyl groups to enhance the solub...

The gelation properties of a zinc porphyrin bearing peripheral urea groups (1 x Zn) were evaluated in the absence and the presence of several diamines. In aromatic solvents such as benzene, toluene and p-xylene, 1 x Zn only provided the precipitate. In contrast, 1 x Zn with 0.5 and 1.0 equiv. of piperazine formed gels, and the gel with 0.5 equiv. of piperazine showed a unique physical property ...

The ring-opening of 3-aminocyclobutanone oximes enables easy generation primary alkyl radicals, capable undergoing an unprecedented strain-release, desulfonylative radical Truce–Smiles rearrangement, providing divergent access to valuable 1,3 diamines and unnatural ?-amino acids. Characterized by mild conditions wide scope migrating species, this protocol allows the modular assembly sp3-aryls u...

To realize the scope of solid-solid reaction, functional solid diamines reacted with 3-ethoxysalicylaldehyde under high-speed ball milling in a solvent-free environment. The findings showed that wide range Salophen ligands could be produced good to excellent yields. In comparison similar synthesis date, current study provided solvent-free, fast high yield, and easy work-up.