Human basal gastric secretion is markedly reduced after oral administration of 10 mg diazepam. This effect lasts for five hours.Gastric nocturnal secretion, collected five hours after the last meal, reveals a decline towards the morning hours with an average of 25% in placebo-treated patients. A comparison between placebo and diazepam reveals a significantly greater decrease of 47% in volume af...

Diazepam (70-150 micrograms/ml) significantly inhibits oxygen consumption by pig kidney embryo cells and causes the cellular ATP level to fall. The maximum inhibitory effect develops after 1.5-2.5 h of diazepam treatment. In isolated mitochondria diazepam inhibits respiration in state 2 and 3u with glutamate and in state 3u with succinate. Ethylrhodamine staining and electron microscopic study ...

Diazepam ingestion along with ethanol is encountered commonly in drug overdose cases. In the present study, the effect of pH and ethanol on the adsorption of diazepam in the simulated gastric fluid and the simulated intestinal fluid onto activated charcoal was determined in vitro. The adsorption behaviors of diazepam in both simulated gastric and intestinal pH onto activated charcoal were studi...

Diazepam is a valuable drug in cases of acute myocardial infarction. The 10 mg intravenous loading dose and the subsequent 15 mg oral dose of diazepam administered three times daily produced safe, pleasant sedation, and reduced the need for analgesics. A much reduced excretion of catecholamines was recorded. It is presumed that diazepam causes a lower stress reaction, which is beneficial in dim...

Intravenous access cannot always be promptly obtained when treating status epilepticus outside the hospital. We compared the efficacy and safety of diazepam rectal gel to IV lorazepam in our long-term care facility for adults with developmental disabilities. Diazepam rectal gel was given more quickly and reliably, reducing total seizure time, potential neuronal injury and other complications. A...

Claustrophobia is associated with cardiovascular magnetic resonance (CMR) due to the nature of the technique and lengthy examination times. We report the incidence and treatment of claustrophobia in a prospective study on the use of intravenous (IV) and oral diazepam for CMR from August 1997 to June 1999 in 1754 adult patients referred for clinical (1226) and research (528) purposes. Patients u...

background and objective: several studies have found that diazepam decreases serum glucose. meanwhile, glibenclamide is commonly used in diabetes treatment. the objective of this study was to survey the treatment impact of diazepam and glibenclamide on blood glucose and serum lipids in mice with type ii diabetes. materials and methods: in this study, 32 male rats were divided into four groups, ...

centrations of diazepam in the blood, but previous studies (7) have shown that a single 10-mg oral dose will, after I to 2 hours, produce concentrations similar to those in patients following a typical dosage regimen of 5 mg, three times daily. This does not imply that shortand longterm diazepam effects will necessarily be the same because of equivalent blood concentrations, nor that healthy vo...

Background: Stress is the causative factor for various diseases and disorders faced by majority of diseased population. The leaves Sambucus nigra (S. nigra) are attributed to neuropharmacological properties as per literature. Considering above, S. hydroalcoholic extract was tested adaptogenic activity in animals. Objective: study deals with evaluation using cold immobilization footshock induced...

Benzodiazepines (BDZ) are widely prescribed in the treatment of anxiety disorders associated to aging. Interestingly, whereas a reciprocal interaction between the GABAergic system and HPA axis has been evidenced, there is to our knowledge no direct evaluation of the impact of BDZ on both hippocampus (HPC) corticosterone concentrations and HPC-dependent memory in stressed middle-aged subjects. W...