introduction drug-induced liver injury is a frequent cause of hepatic dysfunction. several drugs have been identified to cause autoimmune hepatitis (aih). environmental chemicals are capable of triggering a certain degree of liver injury. however, toxin induced aih is rare. conclusions chronic (long-term) exposures to dichlorvos can lead to aih. a detailed inquiry of medical history and liver b...

The literature of pesticide residue analysis is reviewed selectively for the period 1999-2000. Analyses of a wide range of pesticide classes and sample types, as well as some related organic pollutants, are covered. Studies of exposure and monitoring as well as pesticide degradation, persistance, leaching, mobility, and metabolism studies are included.

a 'worst case' laboratory method was employed for evaluating total effect of four pesticides (imidacloprid, dichlorvos, pymetrozine and abamectin) on the nymphs mortality and adults reproduction in orius albidipennis reuter (hemiptera: anthocoridae). the bioassays were carried out in laboratory using drum cell method, under controlled conditions of: 27±1?c, rh of 65±5% and 16-h photo ...

The anti-influenza drug oseltamivir is an ester prodrug activated by hepatic carboxylesterases. Plasma esterases also convert up to 31.8% of the parent compound to the active metabolite after 4 h ex vivo, with wide interindividual variation. This source of error is removed by adding the esterase inhibitor dichlorvos to blood collection tubes.

The possible genotoxic activity of Dichlorvos (2,2-Dichlorovinyl-O,O-dimethyl phosphate/DDVP, CAS No. 62-73-7), an organophosphorus insecticide was investigated employing three cytogenetic end points, i.e. micronucleus (MN) assay, mitotic indices (MI) and chromosome abberation (CA) analysis in vivo. The assays were carried out in hematopoietic bone marrow cells of Mus musculus at concentrations...

During storage, soybean kernels can be attacked by insects, which are preventively controlled with insecticides. Information on the dissipation of insecticide residues is crucial to know their final concentrations in food and establish waiting periods necessary for consumption without health risks, determine minimum period comply national international standards. The aims this study were quanti...