Multidrug resistance (MDR) due to overexpression of P-glycoprotein (P-gp) is a major obstacle that hinders the treatment of hepatocellular carcinoma (HCC). It has been shown that miR-375 inhibits P-gp expression via inhibition of astrocyte elevated gene-1 (AEG-1) expression in HCC, and induces apoptosis in HCC cells by targeting AEG-1 and YAP1. In this study, we prepared lipid-coated hollow mes...

State government, university, and local health department (LHD) partners collaborated to build the geographic information system (GIS) capacity of 5 LHDs in North Carolina. Project elements included procuring hardware and software, conducting individualized and group training, developing data layers, guiding the project development process, coordinating participation in technical conferences, p...

Using the island divertors (ID) of W7-AS and W7-X and the helical divertor (HD) of LHD as examples, the paper presents a comparative divertor transport study for three typical helical devices of different machine-size following two distinct divertor concepts, aiming at identifying common physics issues/effects for mutual validation and combined studies. Based on EMC3/EIRENE simulations supporte...

OBJECTIVE State health reform (Patient Protection and Affordable Care Act [ACA]) policies may impact the work experiences of community health professionals. We examine the extent to which community health professional work experiences differ depending on state Medicaid expansion and health insurance exchange policies. DESIGN Public Health Workforce Interests and Needs Survey (PH WINS) (2014) ...

BACKGROUND Although pulmonary hypertension due to left heart disease (LHD-PH) accounts for the largest proportion of pulmonary hypertension, few reports on the epidemiological analysis of LHD-PH exist. Recently, pulmonary arterial capacitance (PAC) has attracted attention as a possible factor of right ventricular afterload along with pulmonary vascular resistance. We therefore investigated the ...

This paper reviews various global instabilities destabilized by tangential neutral beam injection (NBI) in the Large Helical Device (LHD) plasmas. These global modes are toroidal Alfvén eigenmodes (TAEs), which are also observed in tokamak plasmas, and helicity-induced Alfvén eigenmodes (HAEs) which are observed only in three-dimensional plasmas such as LHD plasmas. Moreover, reversed magnetic ...

OBJECTIVE To determine the etiology of Hilar malignant biliary strictures and the efficacy of hepaticojejunostomy in it's management with or without segmental liver resection. PATIENTS AND METHODS A retrospective study of 33 patients was carried out at Civil Hospital & Lyari General Hospital Karachi. They presented with signs and symptoms of mechanical cholestasis. Study was conducted to find...

OBJECTIVE To learn if the left compared with the right hemisphere of right handed subjects exerts bilateral compared with contralateral motor control when performing precise and coordinated finger movements. METHODS The study investigated intertask differences of manual motor asymmetries such as speed, precision, and independent finger movements, in patients with unilateral lesions of the lef...

In this paper, an attempt has been made to model DPM flow patterns in the vicinity of man riding vehicle(s) operating a coal mine environment. The are modelled using techniques computational fluid dynamics (CFD) and validated field experimental measurements. models show that if vehicle is stationary, particles dispersed towards center gallery. Beyond 20 m downstream vehicle, occupy entire cross...