The effects of S-methyl diethyldithiocarbamate, S-methyl diethylmonothiocarbamate and bis(diethylcarbamoyl) disulphide on sheep liver cytoplasmic aldehyde dehydrogenase were investigated in vitro. The first compound has negligible effect. The second one is a weak inhibitor of the esterase activity of the enzyme and a weaker inhibitor of the dehydrogenase activity. A very low concentration of th...

DETC: diethyldithiocarbamate, DMPO: 5,5-dimethyl-1-pyrroline N-oxide, DNIC: di-nitrosyl-iron complex, DTCS: N-(dithiocarboxy)sarcosine, EDRF: endothelium-derived relaxing factor, EPR, ESR: electron paramagnetic resonance; electron spin resonance, cGMP: cyclic GMP, Hb: hemoglobin, LPS: lipopolysaccharide, Mb: myoglobin, MGD: N-methyl-D-glucamine dithiocarbamate, MNIC: mono-nitrosyl-iron complex,...

Sodium diethyldithiocarbamate (DDTC) has been shown to modulate the myelosuppression that commonly occurs following treatment with anticancer drugs in mice. In order to investigate the mechanism of action of this myeloprotector, murine long-term bone marrow cultures were treated with DDTC alone or were preceded by the anticancer drug cis-diammine(cyclobutanedicarboxylato)platinum(II) (CBDCA), a...

The biocidal activity of 8 triorganotins R3S11X (R = butyl, phenyl, benzyl; X = oxide, chloride, acetate, naphthenate, TV, JV-diethyldithiocarbamate) on brown rot fungi, moulds mixture, benthic organisms, plankton alga Scenedesmus quadricauda, and crop plant has been investigated. The results suggest dependence between lipophilicity of bounded R groups and intensity of unfavourable effect. The ...

We investigated the effect of oxidative stress on the expression of adrenomedullin (AM) mRNA in cultured rat vascular smooth muscle cells (VSMCs), using diethyldithiocarbamate (DDC), which is known to inhibit endogenous Cu, Zn superoxide dismutase (SOD) and to increase superoxide (02-). DDC (10 mM) increased 02 levels produced from rat VSMCs in a time-dependent fashion. Concomitantly, DDC incre...

A new method of indirect determination of Cu(2+) was developed based on square-wave voltammetry by the oxidation of iodide in organic solvent at the liquid/liquid (L/L) interface. The limit of detection for the determination of Cu(2+) in this method was found to be 5 x 10(-4) mol/L, and the concentration ranged up to 1 x 10(-2) mol/L gave a linear limiting current versus concentration response....

A dispersive liquid–liquid microextraction based on solidification of floating organic drop for simultaneous extraction of trace amounts of nickel, cobalt and copper followed by their determination with electrothermal atomic absorption spectrometry was developed. 300 μL of acetone and 1-undecanol was injected into an aqueous sample containing diethyldithiocarbamate complexes of metal ions. For ...